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Pubmed ID :29792369
Publication Date : //

Gene delivery in the cornea: in vitro & ex vivo evaluation of solid lipid nanoparticle-based vectors.


Inflammation is a process that underlies sight-threatening ocular surface diseases, and gene supplementation with the plasmid that encodes for p-IL10 will allow the sustained de novo synthesis of the cytokine to occur in corneal cells, and provide a long-term anti-inflammatory effect. This work describes the development of solid lipid nanoparticle systems for the delivery of p-IL10 to transfect the cornea.

Authors : Vicente-Pascual Mónica , Albano Andrea , Solinís María Á , Serpe Loredana , Rodríguez-Gascón Alicia , Foglietta Federica , Muntoni Elisabetta , Torrecilla Josune , Pozo-Rodríguez Ana Del , Battaglia Luigi ,

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