Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery
Publication Date : //
Autophagy machinery has roles in the defense against microorganisms such as . Lipidated LC3, the marker protein of autophagy, participates in the elimination of by forming a single-membrane phagosome; this process is called LC3-associated phagocytosis (LAP). However, the influence of on autophagic flux is not clear. In this study, we found that inhibited LC3 turnover in macrophages. After the phagocytosis of in macrophages, we observed fewer acridine orange-positive vacuoles and RFP-GFP-LC3 puncta without colocalization with phagocytized . However, phagocytosis of led to LC3 recruitment, but p62 and ATG9A did not colocalize with LC3 or . These effects are due to an MTOR-independent pathway. Nevertheless, we found that the pattern-associated molecular pattern -glucan increased LC3 turnover. In addition, phagocytosis of caused a decrease in BrdU incorporation. Blocking autophagic flux aggravated this effect. Our findings suggest that phagocytosis of decreases autophagic flux but induces LAP in an MTOR-independent manner in macrophages. Occupation of LC3 by recruiting engulfed might contribute to the inhibition of autophagic flux. Our study highlights the coordinated machinery between canonical autophagy and LAP that defends against challenge.
Authors : Duan Zhimin , Chen Qing , Du Leilei , Tong Jianbo , Xu Song , Zeng Rong , Ma Yuting , Chen Xu , Li Min ,
Related products :
52062 Aachen Deutschland
Support Karolina Elandt
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
firstname.lastname@example.org | Gentaur
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Finland Helsset +358942419041
Magyarország Budapest +3619980547
US New York+17185132983
No related Items
Related Genes :
 Phagocytosis of Inhibits Autophagic Flux in Macrophages.
 Clinical Mycobacterium abscessus strain inhibits autophagy flux and promotes its growth in murine macrophages.
 Autophagy is associated with cell fate in the process of macrophage-derived foam cells formation and progress.
 IL-10 restricts dendritic cell (DC) growth at the monocyte-to-monocyte-derived DC interface by disrupting anti-apoptotic and cytoprotective autophagic molecular machinery.
 The Salmonella deubiquitinase SseL inhibits selective autophagy of cytosolic aggregates.
 Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy.
 Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages.
 Interferon regulatory factor-1 regulates the autophagic response in LPS-stimulated macrophages through nitric oxide.
Enter catalog number :