Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29895160
Publication Date : //

Antiviral effect of a derivative of isonicotinic acid enisamium iodide (FAV00A) against influenza virus.


With only a single class of antiviral drugs existing for treatment of influenza (neuraminidase inhibitors), the search for novel effective compounds is urgently needed. We evaluated a low molecular mass compound, enisamium iodide (FAV00A), against influenza virus infections in primary differentiated normal human bronchial epithelial (NHBE) cells, and in ferrets. FAV00A (500 µg/ml) markedly inhibited influenza virus replication and reduced viral M-gene expression in NHBE cells. Treatment of ferrets with FAV00A (200 mg/kg once daily for 7 days) initiated 24 h after inoculation with 105 TCID50 of influenza A/Wisconsin/67/2005 (H3N2) virus resulted in a significant decrease in virus titers in the upper respiratory tract. Our data show that FAV00A exhibits an antiviral effect against influenza virus in NHBE cells and provides some benefits in a ferret model. Thus, further Keywords: antiviral agents; enisamium iodide; influenza virus; MDCK cells; NHBE cells; ferrets.

Authors : Cocking D , Cinatl J , Boltz D A , Peng X , Johnson W , Muzzio M , Syarkevych O , Kostyuk G , Goy A , Mueller L , Margitich V I ,

Related products :

Catalog number Product name Quantity
25108-37-6 Isonicotinic acid potassium salt Isonicotinic acid potassi 1g
16887-79-9 Isonicotinic acid sodium salt Isonicotinic acid sodiu 1g
1360-21-5 Isonicotinic acid N_oxide Isonicotinic acid N_oxid 1g
25635-24-9 Isonicotinic acid allyl ester Isonicotinic acid allyl es 1g
7529-20-6 3_Amino isonicotinic acid 3_Amino isonicotinic aci 1g
orb60561 Nitazoxanide Nitazoxanide(Alinia, Annita) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 25 mg
orb81796 Influenza Virus H1N1 New Caledonia 20_99 IV 116 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain A_ New Caledonia_20_99 IVR 116. The Influenza Virus was 10
orb81792 Influenza Virus Malaysia 2506_04 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain B_Malaysia_2506_04. The Influenza Virus was purified by Ultracentrifug 10
orb81789 Influenza Virus Qingdao 102_91 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain B_Qingdao_102_91. The Influenza Virus was purified by Ultracentrifugatio 10
orb81794 Influenza Virus Florida 04_06 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain B_Florida_04_06. The Influenza Virus was purified by Ultracentrifugation 10
orb81790 Influenza Virus Tokio 53_99 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain B_Tokio_53_99. The Influenza Virus was purified by Ultracentrifugation with 10
orb81791 Influenza Virus Victoria 504_00 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain B_Victoria_504_00. The Influenza Virus was purified by Ultracentrifugat 10
orb81793 Influenza Virus Florida 07_04 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain B_Florida_07_04. The Influenza Virus was purified by Ultracentrifugation 10
orb81802 Influenza Virus H3N2 Wisconsin 67_05 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain A_Wisconsin_67_05. The Influenza Virus was purified by Ultracentri 10
orb81799 Influenza Virus H3N2 Shangdong 9_93 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain A_Shandong_9_93. The Influenza Virus was purified by Ultracentrifug 10
orb81801 Influenza Virus H3N2 Panama 2007_99 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain A_Panama_2007_99. The Influenza Virus was purified by Ultracentrifu 10
orb81795 Influenza Virus H1N1 Beijing 262_95 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain A_Beijing_262_95. The Influenza Virus was purified by Ultracentrifu 10
orb81803 Influenza Virus H3N2 Brisbane 10_07 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain A_Brisbane_10_07. The Influenza Virus was purified by Ultracentrifu 10
orb81797 Influenza Virus H1N1 Taiwan 1_86 protein Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza virus, strain A_Taiwan_1_86. The Influenza Virus was purified by Ultracentrifugation 10
19615-22 Isonicotinic Acid 〔Pyridine‐4‐carboxylic Acid〕 CAS: 55-22-1 25G
19615-35 Isonicotinic Acid 〔Pyridine‐4‐carboxylic Acid〕 CAS: 55-22-1 500G
19615-35 Isonicotinic Acid 〔Pyridine‐4‐carboxylic Acid〕 500G
19615-22 Isonicotinic Acid 〔Pyridine‐4‐carboxylic Acid〕 25G
55-22-1 Isonicotinic acid Isonicotinic acid 1g
orb60829 Raf265 derivative Raf265 derivative is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 10 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur