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Pubmed ID :29897914
Publication Date : //

The effects of repeated automated plasmapheresis in goats (Capra hircus) in response to vaccination with purified influenza hemagglutinin proteins.


Seasonal influenza is a contagious respiratory illness that annually affects millions of people worldwide. To identify currently circulating influenza virus subtypes, the Centers for Disease Control and Prevention's International Reagent Resource distributes the World Health Organization (WHO) influenza reagent kits, which are used globally by testing laboratories for influenza surveillance. The data generated by the kits aid in strain selection for the influenza vaccine each season. The use of animals to produce high quality and quantities of antibodies is critical to the production of these kits. In this study, we assessed the effects and efficacy of repeated sampling from automated plasmapheresis in goats. Analysis of blood samples demonstrated that repeated automated plasmapheresis procedures did not adversely affect the immediate or long-term health of goats. Further, our results indicate that repeated plasmapheresis in goats was capable of generating 2 liters of antibody-rich plasma per goat per week. This volume is sufficient to produce enough WHO influenza kits to conduct over 1 million tests. Thus, we have shown that the rapid production of plasma in goats can positively impact the public health preparedness and response to influenza.

Authors : Taylor Willie D , Langham Gregory L , Weed James L , Rowe Thomas , Song Wei , Isenberg Kristin A , Xu Xiyan , Wentworth David E , Lathrop George , Powell Nathaniel ,

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Catalog number Product name Quantity
Path-SS-C.hircus Capra hircus (Goat)
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SEA079Cp ELISA Kit for Interleukin 6 (IL6) Capra hircus; Caprine (Goat) 96T
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E90079Cp ELISA Kit for Interleukin 6 (IL6) Organism: Capra hircus; Caprine (Goat) 96T
E91409Cp ELISA Kit for Hemoglobin (HB) Organism: Capra hircus; Caprine (Goat) 96T
E90028Cp ELISA Kit for Erythropoietin (EPO) Organism: Capra hircus; Caprine (Goat) 96T
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E90028Cp ELISA Kit for Erythropoietin (EPO) Organism Capra hircus; Caprine (Goat) 96T
E90108Cp ELISA Kit for Osteoprotegerin (OPG) Organism: Capra hircus; Caprine (Goat) 96T
E90073Cp ELISA Kit for Interleukin 2 (IL2) Organism: Capra hircus; Caprine (Goat) 96T
E90078Cp ELISA Kit for Interleukin 5 (IL5) Organism Capra hircus; Caprine (Goat) 96T
E90076Cp ELISA Kit for Interleukin 3 (IL3) Organism Capra hircus; Caprine (Goat) 96T
E90077Cp ELISA Kit for Interleukin 4 (IL4) Organism Capra hircus; Caprine (Goat) 96T
E90079Cp ELISA Kit for Interleukin 6 (IL6) Organism Capra hircus; Caprine (Goat) 96T
E90080Cp ELISA Kit for Interleukin 8 (IL8) Organism Capra hircus; Caprine (Goat) 96T
E90296Cp ELISA Kit for Lactoperoxidase (LPO) Organism Capra hircus; Caprine (Goat) 96T
E90296Cp ELISA Kit for Lactoperoxidase (LPO) Organism: Capra hircus; Caprine (Goat) 96T
E90084Cp ELISA Kit for Leptin (LEP) Organism Capra hircus; Caprine (Goat) 96T


 

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