Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29902248
Publication Date : //

Exacerbation of hepatic injury during rodent malaria by myeloid-related protein 14.


Hepatic dysfunction is one of the clinical features in severe malaria. However, the mechanism of hepatic injury during malaria is still unknown. Myeloid-related protein (MRP) 14 is abundantly expressed by myeloid cells and involved in various inflammatory diseases. We previously reported that serum MRP14 is elevated in mice infected with Plasmodium berghei ANKA. In order to verify whether extracellular MRP14 is involved in the pathology of hepatic injury during rodent malaria, we intravenously administrated recombinant MRP14 (rMRP14) to mice infected with P. berghei ANKA. The administration of rMRP14 did not affect parasite number or hematocrit. On the other hand, the hepatic injury was exacerbated in rMRP14-treated mice, and their serum concentration of hepatic enzymes increased significantly more than PBS-treated controls. Immunohistochemical analysis of the liver showed that more MRP14+ macrophages accumulated in rMRP14-treated mice than PBS-treated controls after infection. The administration of rMRP14 also promotes the up-regulation of pro-inflammatory molecules in the liver, such as iNOS, IL-1β, IL-12, and TNF-α. Even in the absence of Plasmodium infection, administration of rMRP14 could induce the accumulation of MRP14+ macrophages and up-regulation of the pro-inflammatory molecules in the liver of naïve mice. The results indicate that MRP14 promotes the accumulation of MRP14+ cells and the up-regulation of pro-inflammatory molecules and NO, which amplify inflammatory cascade leading to hepatic injury. In conclusion, MRP14 is a one of key molecules for liver inflammation during rodent malaria.

Authors : Mizobuchi Haruka , Fujii Wataru , Isokawa Shoko , Ishizuka Kanna , Wang Yihan , Watanabe Sayoko , Sanjoba Chizu , Matsumoto Yoshitsugu , Goto Yasuyuki ,

Related products :

Catalog number Product name Quantity
EIAAB26939 Bos taurus,Bovine,NENF,Neudesin,Neuron-derived neurotrophic factor,SCIRP10-related protein,Spinal cord injury-related protein 10
EIAAB26937 Nenf,Neudesin,Neuron-derived neurotrophic factor,Rat,Rattus norvegicus,Scirp10,SCIRP10-related protein,Spinal cord injury-related protein 10
U2085m CLIA kit 425O18-1,Angiopoietin-like protein 4,Angiopoietin-related protein 4,Angptl4,Farp,Fasting-induced adipose factor,Fiaf,Hepatic fibrinogen_angiopoietin-related protein,HFARP,Mouse,Mus musculus, 96T
E2085m ELISA kit 425O18-1,Angiopoietin-like protein 4,Angiopoietin-related protein 4,Angptl4,Farp,Fasting-induced adipose factor,Fiaf,Hepatic fibrinogen_angiopoietin-related protein,HFARP,Mouse,Mus musculus 96T
E2085m ELISA 425O18-1,Angiopoietin-like protein 4,Angiopoietin-related protein 4,Angptl4,Farp,Fasting-induced adipose factor,Fiaf,Hepatic fibrinogen_angiopoietin-related protein,HFARP,Mouse,Mus musculus,Ng27 96T
U2085m CLIA 425O18-1,Angiopoietin-like protein 4,Angiopoietin-related protein 4,Angptl4,Farp,Fasting-induced adipose factor,Fiaf,Hepatic fibrinogen_angiopoietin-related protein,HFARP,Mouse,Mus musculus,Ng27, 96T
E2085r ELISA kit Angiopoietin-like protein 4,Angiopoietin-related protein 4,Angptl4,Hepatic fibrinogen_angiopoietin-related protein,HFARP,Rat,Rattus norvegicus 96T
U2085r CLIA kit Angiopoietin-like protein 4,Angiopoietin-related protein 4,Angptl4,Hepatic fibrinogen_angiopoietin-related protein,HFARP,Rat,Rattus norvegicus 96T
U2085r CLIA Angiopoietin-like protein 4,Angiopoietin-related protein 4,Angptl4,Hepatic fibrinogen_angiopoietin-related protein,HFARP,Rat,Rattus norvegicus 96T
E2085r ELISA Angiopoietin-like protein 4,Angiopoietin-related protein 4,Angptl4,Hepatic fibrinogen_angiopoietin-related protein,HFARP,Rat,Rattus norvegicus 96T
E1793r ELISA kit Calgranulin-B,Migration inhibitory factor-related protein 14,Mrp14,MRP-14,Myeloid-related protein 14,p14,Protein S100-A9,Rat,Rattus norvegicus,S100 calcium-binding protein A9,S100a9 96T
E1793r ELISA Calgranulin-B,Migration inhibitory factor-related protein 14,Mrp14,MRP-14,Myeloid-related protein 14,p14,Protein S100-A9,Rat,Rattus norvegicus,S100 calcium-binding protein A9,S100a9 96T
U1793r CLIA kit Calgranulin-B,Migration inhibitory factor-related protein 14,Mrp14,MRP-14,Myeloid-related protein 14,p14,Protein S100-A9,Rat,Rattus norvegicus,S100 calcium-binding protein A9,S100a9 96T
U1793r CLIA Calgranulin-B,Migration inhibitory factor-related protein 14,Mrp14,MRP-14,Myeloid-related protein 14,p14,Protein S100-A9,Rat,Rattus norvegicus,S100 calcium-binding protein A9,S100a9 96T
E2085h ELISA kit Angiopoietin-like protein 4,Angiopoietin-related protein 4,ANGPTL4,ARP4,Hepatic fibrinogen_angiopoietin-related protein,HFARP,HFARP,Homo sapiens,Human,PGAR,PP1158,PSEC0166,UNQ171_PRO197 96T
U2085h CLIA Angiopoietin-like protein 4,Angiopoietin-related protein 4,ANGPTL4,ARP4,Hepatic fibrinogen_angiopoietin-related protein,HFARP,HFARP,Homo sapiens,Human,PGAR,PP1158,PSEC0166,UNQ171_PRO197 96T
E2085h ELISA Angiopoietin-like protein 4,Angiopoietin-related protein 4,ANGPTL4,ARP4,Hepatic fibrinogen_angiopoietin-related protein,HFARP,HFARP,Homo sapiens,Human,PGAR,PP1158,PSEC0166,UNQ171_PRO197 96T
U2085h CLIA kit Angiopoietin-like protein 4,Angiopoietin-related protein 4,ANGPTL4,ARP4,Hepatic fibrinogen_angiopoietin-related protein,HFARP,HFARP,Homo sapiens,Human,PGAR,PP1158,PSEC0166,UNQ171_PRO197 96T
20-372-60008 core-binding factor.alpha subunit 2 - Mouse monoclonal anti-human CBFA2T2 antibody; MTG8-like protein; MTG8-related protein 1; Myeloid translocation-related protein 1; ETO homologous on chromosome 20; 0.1 mg
EIAAB25666 CBFA2T2,EHT,ETO homologous on chromosome 20,Homo sapiens,Human,MTG8-like protein,MTG8-related protein 1,MTGR1,Myeloid translocation-related protein 1,p85,Protein CBFA2T2
E02M0341 Rat myeloid-related protein 96 Tests/kit
E03M0341 Mouse myeloid-related protein 96 Tests/kit
E04M0341 Rabbit myeloid-related protein 96 Tests/kit
E07M0341 Porcine myeloid-related protein 96 Tests/kit
E11M0341 Bovine myeloid-related protein 96 Tests/kit


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur