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Pubmed ID :29907292
Publication Date : //

Nanobody-based dual epitopes protein identification (DepID) assay for measuring soluble CD38 in plasma of multiple myeloma patients.


CD38 is a surface membrane antigen highly expressed in malignant blood cells, such as multiple myeloma (MM). A soluble form of CD38 (sCD38) is also present in the plasma, deriving likely from the shedding from the cells. The plasma levels of sCD38 should thus correlate closely with the proliferation of the MM cells, allowing the development of a simple diagnostic blood test for monitoring the progress of the disease. However, the plasma sCD38 levels are extremely low, requiring the design of a highly sensitive and specific assay.

Authors : Li Ting , Li Song Lu , Fang Cheng , Hou Yun Nan , Zhang Qiaoxia , Du Xin , Lee Hon Cheung , Zhao Yong Juan ,

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