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Pubmed ID :29911685
Publication Date : //

Docetaxel Treatment in PTEN- and ERG-aberrant Metastatic Prostate Cancers.


Loss of PTEN is a common genomic aberration in castration-resistant prostate cancer (CRPC) and is frequently concurrent with ERG rearrangements, causing resistance to next-generation hormonal treatment (NGHT) including abiraterone. The relationship between PTEN loss and docetaxel sensitivity remains uncertain.

Authors : Rescigno Pasquale , Lorente David , Dolling David , Ferraldeschi Roberta , Rodrigues Daniel Nava , Riisnaes Ruth , Miranda Susana , Bianchini Diletta , Zafeiriou Zafeiris , Sideris Spyridon , Ferreira Ana , Figueiredo Ines , Sumanasuriya Semini , Mateo Joaquin , Perez-Lopez Raquel , Sharp Adam , Tunariu Nina , de Bono Johann S ,

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