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Pubmed ID :29912453
Publication Date : //

Induction of Cross-Clade Antibody and T-Cell Responses by a Modified Vaccinia Virus Ankara-Based Influenza A(H5N1) Vaccine in a Randomized Phase 1/2a Clinical Trial.


High-pathogenicity avian influenza viruses continue to circulate in poultry and wild birds and occasionally infect humans, sometimes with fatal outcomes. Development of vaccines is a priority to prepare for potential pandemics but is complicated by antigenic variation of the surface glycoprotein hemagglutinin. We report the immunological profile induced by human immunization with modified vaccinia virus Ankara (MVA) expressing the hemagglutinin gene of influenza A(H5N1) virus A/Vietnam/1194/04 (rMVA-H5).

Authors : de Vries Rory D , Altenburg Arwen F , Nieuwkoop Nella J , de Bruin Erwin , van Trierum Stella E , Pronk Mark R , Lamers Mart M , Richard Mathilde , Nieuwenhuijse David F , Koopmans Marion P G , Kreijtz Joost H C M , Fouchier Ron A M , Osterhaus Albert D M E , Sutter Gerd , Rimmelzwaan Guus F ,

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