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Pubmed ID :29924888
Publication Date : //

Nitidine chloride represses Mcl-1 protein via lysosomal degradation in oral squamous cell carcinoma.


We have shown previously that nitidine chloride (NC) induces apoptosis via inhibition of signal transducer and activator of transcription 3 (STAT3). However, its downstream molecules are not fully understood yet. Here, we report that NC as STAT3 inhibitor downregulates myeloid cell leukemia-1 (Mcl-1) protein in HSC-3 and HSC-4 human oral squamous cell carcinoma (OSCC) cells and a nude mouse tumor xenograft model.

Authors : Yang In-Hyoung , Jung Won , Kim Lee-Han , Shin Ji-Ae , Cho Nam-Pyo , Hong Seong Doo , Hong Kyoung-Ok , Cho Sung-Dae ,

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