Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29928669
Publication Date : //

Cholecystokinin Receptor-Targeted Polyplex Nanoparticle Inhibits Growth and Metastasis of Pancreatic Cancer.


Pancreatic ductal adenocarcinoma (PDAC) remains the most aggressive malignancy with the lowest 5-year survival rate of all cancers in part owing to the lack of tumor-specific therapy and the rapid metastatic nature of this cancer. The gastrointestinal peptide gastrin is a trophic peptide that stimulates growth of PDAC in an autocrine fashion by interaction with the cholecystokinin receptor that is overexpressed in this malignancy.

Authors : Burks Julian , Nadella Sandeep , Mahmud Abdullah , Mankongpaisarnrung Charoen , Wang Juan , Hahm Jong-In , Tucker Robin D , Shivapurkar Narayan , Stern Stephan T , Smith Jill P ,

Related products :

Catalog number Product name Quantity
orb61277 Pazopanib Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a_beta, and c-kit that blocks tumor growth and inhibits angiogenesis 100 mg
31-050 MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 w 0.05 mg
31-051 MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 whil 0.1 mg
30-121 C21orf33 inhibits both estrogen- and heregulin-beta1-stimulated growth of breast cancer cells, and further suggests that growth inhibition induced in these cells by all-trans retinoic acid occurs via 0.1 mg
orb61378 Vargatef Vargatef is an indolinone derivative that potently inhibits vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and fibroblast growth factor r 25 mg
GB-52550 Cancer and metastasis related antibodies : Anti-Connective Tissue Growth Factor (CTGF), Mouse-monoclonal Antibody 100ul
GB-10520 Cancer and metastasis related antibodies : Anti-Connective Tissue Growth Factor (CTGF), Rabbit-Polyclonal Antibody 100ug
GB-10516 Cancer and metastasis related antibodies : Anti-Connective Tissue Growth Factor (CTGF), Mouse-Polyclonal Antibody 100μl
Pancreas - PAC481 Pancreatic cancer tissue array contains 20 cases of pancreatic cancers and 4 cases of normal and non_malignant pancreatic tissues. 2mm
PY-10034 Cancer and metastasis related antibodies : Anti-Breast cancer 1(BRCA1),Chicken-Poly 100μg
EIAAB06107 CCK1-R,CCK-A receptor,CCKAR,CCK-AR,CCKRA,Cholecystokinin receptor type A,Cholecystokinin-1 receptor,Homo sapiens,Human
orb61328 Enzastaurin Enzastaurin inhibits PKCbeta, PKCalpha, PKCγ and PKCε with IC50s of 0.006, 0.039, 0.083 and 0.110 µM, respectively. Enzastaurin apparently inhibits tumor growth via multiple mechanisms. Fo 25 mg
EIAAB06103 CCK1-R,CCK-A receptor,CCKAR,CCK-AR,Cholecystokinin receptor type A,Cholecystokinin-1 receptor,Oryctolagus cuniculus,Rabbit
EIAAB06104 CCK1-R,CCK-A receptor,Cckar,CCK-AR,Cholecystokinin receptor type A,Cholecystokinin-1 receptor,Rat,Rattus norvegicus
EIAAB06105 CCK1-R,CCK-A receptor,Cckar,CCK-AR,Cholecystokinin receptor type A,Cholecystokinin-1 receptor,Mouse,Mus musculus
orb61244 Erlotinib Erlotinib hydrochloride is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. For research use only. 100 mg
PA207b High_density (69 cases_207 cores), multiple pancreatic cancer (I_4 grade) and normal pancreatic tissue array BLOCK
PA207 High_density (69 cases_207 cores), multiple pancreatic cancer (1_3 grade) and normal pancreatic tissue array, replaced by PA2072
PA2081 Pancreatic disease spectrum (pancreatic cancer progression) tissue array with pathology grade and TNM information, 101 cases_208 cores
18-461-10739 Cholecystokinin type A receptor - CCK-A receptor; CCK-AR; Cholecystokinin-1 receptor; CCK1-R Polyclonal 0.05 ml
18-461-10740 Cholecystokinin type A receptor - CCK-A receptor; CCK-AR; Cholecystokinin-1 receptor; CCK1-R Polyclonal 0.05 ml
PA2081 Pancreatic disease spectrum (pancreatic cancer progression) tissue array with pathology grade and TNM information, 101 cases_208 cores; ihc Anti-Actin confirmed
PA207b High-density (69 cases_207 cores), multiple pancreatic cancer (I-4 grade) and normal pancreatic tissue array block; ihc Anti-Cytokeratin (CK) confirmed
PA207 High-density (69 cases_207 cores), multiple pancreatic cancer (1-3 grade) and normal pancreatic tissue array, replaced by PA2072; ihc Anti-Cytokeratin (CK) confirmed
orb60366 Isotretinoin It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. For research use only. 1 g


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur