Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :29928918
Publication Date : //

Combined exposure to carbon disulfide and low-frequency noise reversibly affects vestibular function.


Chronic occupational exposure to carbon disulfide (CS2) has debilitating motor and sensory effects in humans, which can increase the risk of falls. Although no mention of vestibulotoxic effects is contained in the literature, epidemiological and experimental data suggest that CS2 could cause low-frequency hearing loss when associated with noise exposure. Low-frequency noise might also perturb the peripheral balance receptor through an as-yet unclear mechanism. Here, we studied how exposure to a low-frequency noise combined with 250-ppm CS2 affected balance in rats. Vestibular function was tested based on post-rotary nystagmus recorded by a video-oculography system. These measurements were completed by behavioral tests and analysis of the cerebellum to measure expression levels for gene expression associated with neurotoxicity. Assays were performed prior to and following a 4-week exposure, and again after a 4-week recovery period. Functional measurements were completed by histological analyses of the peripheral organs.Nystagmus was unaltered by exposure to noise alone, while CS2 alone caused a moderate 19% decrease of the saccade number. In contrast, coexposure to 250-ppm CS2 and low-frequency noise decreased both saccade number and duration by 33% and 34%, respectively. After four weeks, recovery was only partial but measures were not significantly different from pre-exposure values. Real-time quantitative polymerase chain reaction (RT-qPCR) analysis of cerebellar tissue revealed a slight but significant modification in expression levels for two genes linked to neurotoxicity in CS2-exposed animals. However, neither histopathological changes to the peripheral receptor nor behavioral differences were observed. Based on all these results, we propose that the effects of CS2 were due to reversible neurochemical disturbance of the efferent pathways managing post-rotatory nystagmus. Because the nervous structures involving the vestibular function appear particularly sensitive to CS2, post-rotary nystagmus could be used as an early, non-invasive measurement to diagnose CS2 intoxication as part of an occupational conservation program.

Authors : Chalansonnet Monique , Carreres-Pons Maria , Venet Thomas , Thomas Aurélie , Merlen Lise , Seidel Carole , Cosnier Frédéric , Nunge Hervé , Pouyatos Benoît , Llorens Jordi , Campo Pierre ,

Related products :

Catalog number Product name Quantity
CC2800 Carbon disulfide 4L
CC2800 Carbon disulfide 500ML
CC2800 Carbon disulfide 500ML
CC2800 Carbon disulfide 4L
C04622 Carbon disulfide 95 percent 1 L
C04622 Carbon disulfide 95 percent
M28981282 Carbon disulfide, HPLC Grade CAS: [75-15-0] 500 ml
RC120009 TOC_TIC Calibration Set 1mg_L Carbon 0.5mg_L Carbon (1xRC120002&1xRC120008) 6 x 35ml
TOIC308 TOC TIC Mixed Standard 30mg l Organic Carbon, 8mg l Inorganic Carbon 500ml
B452 Carbon Utilisation Agar (ISP Medium No.9) USE : For characterization of Streptomyces on the basis of carbon utilization. 5x500gm
TOIC308 TOC_TIC Mixed Standard 30mg_l Organic Carbon, 8mg_l Inorganic Carbon 500ml
B563 ISP Medium No.9 (Carbon Utilisation Agar) USE : For characterization of Streptomyces on the basis of carbon utilization. 5x500gm
B452 Carbon Utilisation Agar (ISP Medium No.9) USE For characterization of Streptomyces on the basis of carbon utilization. Qty per Litre of Medium: 26,67
B563 ISP Medium No.9 (Carbon Utilisation Agar) USE For characterization of Streptomyces on the basis of carbon utilization. Qty per Litre of Medium: 26,67
RC120009 TOC TIC Calibration Set 1mg L Carbon 0.5mg L Carbon (1xRC120002&1xRC120008) 6 x 35ml
29-983 CSF1 is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought t 0.05 mg
27-767 Prenylated proteins contain one of two isoprenoid lipids, either the 15-carbon farnesyl or the 20-carbon geranylgeranyl, covalently attached to cysteine residues at or near their C terminus. PCYOX1 is 0.1 mg
NRE-2 Noise Reduction Enclosure for Bullet Blender homogenizer
BB50-DX-CE Bullet Blender 50-DX homogenizer, CE certified, for up to 8 samples in 50 mL tubes, with air cooling and noise insulation.
M1295 Trifluoroacetamidoiminobiotin NHS ester, Reversibly binds to avidin preventing protein denaturation during purification, 10mg
orb61313 Brefeldin A1 Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus. For research use only. 10 mg
EIAAB08247 Carbon catabolite repressor protein 4 homolog,CCR4 carbon catabolite repression 4-like,CCR4-NOT transcription complex subunit 6,Cnot6,Cytoplasmic deadenylase,Rat,Rattus norvegicus
099C A4224 Inhalation Exposure System, 240V, CE
099C A4212 Inhalation Exposure System, 120V
099C A4224 Inhalation Exposure System, 240V, CE


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur