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Pubmed ID :29970004
Publication Date : //

BROCKMAN: deciphering variance in epigenomic regulators by k-mer factorization.


Variation in chromatin organization across single cells can help shed important light on the mechanisms controlling gene expression, but scale, noise, and sparsity pose significant challenges for interpretation of single cell chromatin data. Here, we develop BROCKMAN (Brockman Representation Of Chromatin by K-mers in Mark-Associated Nucleotides), an approach to infer variation in transcription factor (TF) activity across samples through unsupervised analysis of the variation in DNA sequences associated with an epigenomic mark.

Authors : de Boer Carl G , Regev Aviv ,

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