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Pubmed ID :30082522
Publication Date : //

Follistatin-Like 1 Promotes Bleomycin-Induced Pulmonary Fibrosis through the Transforming Growth Factor Beta 1/Mitogen-Activated Protein Kinase Signaling Pathway.


Follistatin-like 1 (FSTL1) is a novel profibrogenic factor that induces pulmonary fibrosis (PF) through the transforming growth factor-beta 1 (TGF-β1)/Smad signaling. Little is known about its effects on PF through the non-Smad signaling, like the mitogen-activated protein kinase (MAPK) pathway. Therefore, this study aimed to investigate the role of FSTL1 in PF through the MAPK signaling pathway and its mechanisms in lung fibrogenesis.

Authors : Jin Yan-Kun , Li Xiao-He , Wang Wang , Liu Jie , Zhang Wei , Fang Yin-Shan , Zhang Zhi-Fei , Dai Hua-Ping , Ning Wen , Wang Chen ,

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