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Pubmed ID :30086574
Publication Date : //

Plasma Proteolytic Cascade Activation during Neonatal Cardiopulmonary Bypass Surgery.


 Neonates undergoing cardiopulmonary bypass (CPB) surgery to correct congenital heart defects often experience excessive bleeding. Exposure of blood to artificial materials during CPB may activate coagulation, complement and inflammatory pathways. In addition, the surgical stress placed on the haemostatic system may result in cross-activation of other plasma proteolytic cascades, which could further complicate physiological responses to the surgical procedure and post-operative recovery. Plasma protease inhibitors undergo distinct conformational changes upon interaction with proteases, and, thereby, can serve as endogenous biosensors to identify activation of the different proteolytic cascades. We tested the hypothesis that changes in the concentration and conformation of protease inhibitors regulating plasma proteolytic cascades during neonatal CPB are associated with post-operative bleeding.

Authors : Maroney Susan A , Peterson Julie A , Zwifelhofer Wes , Martinez Nicholas D , Yan Ke , Bercovitz Rachel S , Woods Ronald K , Mast Alan E ,

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