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MicroRNAs (miRNAs), a class of emerging small non-coding RNAs, serve as vital players in modulating multiple biological processes via the post-transcriptional regulation of gene expression. Dysregulated expression of miRNAs in liver cancer is well documented, and the involvement of miRNAs in liver cancer initiation and progression has also been described. Cancer stem cells (CSCs) are a subset of cells known to be at the root of cancer recurrence and resistance to therapy. In this review, we highlight recent reports indicating that miRNAs participate in the regulation of liver cancer stem cells (LCSCs). The signaling pathway, TGF-beta signaling pathway, JAK/STAT signaling pathway and epithelial-mesenchymal transition (EMT) are all closely correlated with the miRNA modulation of LCSCs. In addition, several miRNAs have been demonstrated to be involved in the regulation of LCSCs in response to therapy sensitivity. Targeting LCSCs by regulating the expression of these miRNAs represents a potential therapeutic strategy for treating cancer drug resistance, metastasis and recurrence in the near future.
Authors : Lou Weiyang , Liu Jingxing , Gao Yanjia , Zhong Guansheng , Ding Bisha , Xu Liang , Fan Weimin ,
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WP1019: FAS pathway and Stress induction of HSP regulation
WP1043: Calcium Regulation in the Cardiac Cell
WP1062: Regulation of Actin Cytoskeleton
WP1111: Prostaglandin Synthesis and Regulation
WP1138: FAS pathway and Stress induction of HSP regulation
WP1159: Calcium Regulation in the Cardiac Cell
WP1178: Regulation of Actin Cytoskeleton
WP1365: Calcium Regulation in the Cardiac Cell
WP1380: Regulation of Actin Cytoskeleton
WP1403: AMPK signaling
WP1425: BMP signalling and regulation
WP1449: Regulation of toll-like receptor signaling pathway
WP1530: miRNA regulation of DNA Damage Response
WP1578: BMP signalling and regulation
WP1589: Folate-Alcohol and Cancer Pathway
WP1603: Nicotine Activity on Chromaffin Cells
WP1820: Gap junction trafficking and regulation
WP1872: Neurotransmitter uptake and Metabolism In Glial Cells
WP1896: Regulation of Apoptosis
WP1897: Regulation of beta-cell development
WP1898: Regulation of DNA replication
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1900: Regulation of mitotic cell cycle
WP1968: genetic alternations of lung cancer
WP1971: Integrated Cancer pathway
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