Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :30118404
Publication Date : //

Effects of placental growth factor deficiency on behavior, neuroanatomy, and cerebrovasculature of mice.

Preeclampsia, a hypertensive syndrome occurring in 3-5% of human pregnancies, has lifelong health consequences for fetuses. Cognitive ability throughout life is altered, and adult stroke risk is increased. One potential etiological factor for altered brain development is low concentrations of proangiogenic placental growth factor (PGF). Impaired PGF production may promote an antiangiogenic fetal environment during neural and cerebrovascular development. We previously reported delayed vascularization of the hindbrain, altered retinal vascular organization, and less connectivity in the circle of Willis in Pgf mice. We hypothesized Pgf mice would have impaired cognition and altered brain neuroanatomy in addition to compromised cerebrovasculature. Cognitive behavior was assessed in adult Pgf and Pgf mice by four paradigms followed by postmortem high-resolution MRI of neuroanatomy. X-ray microcomputed tomography imaging investigated the three-dimensional cerebrovascular geometry in another cohort. Pgf mice exhibited poorer spatial memory, less depressive-like behavior, and superior recognition of novel objects. Significantly smaller volumes of 10 structures were detected in the Pgf compared with Pgf brain. Pgf brain had more total blood vessel segments in the small-diameter range. Lack of PGF altered cognitive functions, brain neuroanatomy, and cerebrovasculature in mice. Pgf mice may be a preclinical model for the offspring effects of low-PGF preeclampsia gestation.

Authors : Kay Vanessa R , Rätsep Matthew T , Cahill Lindsay S , Hickman Andrew F , Zavan Bruno , Newport Margaret E , Ellegood Jacob , Laliberte Christine L , Reynolds James N , Carmeliet Peter , Tayade Chandrakant , Sled John G , Croy B Anne ,

Related products :

Catalog number Product name Quantity
29-683 GH2 is a member of the somatotropin_prolactin family of hormones which play an important role in growth control. Mutations in its gene lead to placental growth hormone_lactogen deficiency.The protein 0.1 mg
30-204 Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are med 0.1 mg
20-272-190323 Placental Growth Factor - Mouse monoclonal [37203.111] to Placental Growth Factor Monoclonal 0.1 mg
ASCITE-1 Custom Production of Ascites in Balb c mice (min 20 mice @$30 mice plus; $300 per cell line for cell culture) 1
PGK1 PGF Gene placental growth factor
GTX10966 Placental Growth Factor [37203.111] 100 µg
201-20-4180 PGF{placental growth factor}rabbit.pAb 0.2ml
NB120-10966 Placental Growth Factor 0.1 mg
EH022 Placental Growth Factor Elisa Kit 96T
GTX10966 Placental Growth Factor [37203.111] 100 µg
orb80357 Placental Ovine Growth Hormone protein Placental Growth Hormone Ovine Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 191 amino acids and having a molecular m 100
E-EL-R0742 Rat PGF_PLGF (Placental Growth Factor) ELISA Kit 96T
GWB-ZZD107 Human Placental Growth Factor ELISA Kit
GWB-E05AA2 Placental Growth Factor [37203.111], Antibody
GWB-T00609 Placental Growth Factor (PLGF) Peptide
K01366G Placental Growth Factor (PLGF)Goat Aff.Pur. 100ug
GWB-BD8FD9 Placental Growth Factor-1 (PLGF-1) Recombinant
10-783-79256 RECOMBINANT HUMAN PLACENTAL GROWTH HORMONE - Placental lactogen 0.2 mg
10-783-79255 RECOMBINANT HUMAN PLACENTAL GROWTH HORMONE - Placental lactogen 0.1 mg
PR-428 Proteins: GH-20K, placental Placental Growth Hormone-20Khuman, recombinant, E. coli 100
PR-428 GH_20K, placental Placental Growth Hormone_20K human, recombinant, E. coli 100µg
PR-428 GH_20K, placental Placental Growth Hormone_20K human, recombinant, E. coli 100 µg
PR-428 GH-20K, placental Placental Growth Hormone-20K human, recombinant, E. coli 100
PR-428 GH-20K, placental Placental Growth Hormone-20Khuman, recombinant, E. coli 100
A01349H Placental Growth Factor (PLGF)Synthetic Purified 100ug


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur

Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017


france@gentaur.com | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur