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Pubmed ID :30205157
Publication Date : //

Differential regulation of cytokine and chemokine expression by MK2 and MK3 in airway smooth muscle cells.


Airway smooth muscle (ASM) contributes to local inflammation and plays an immunomodulatory role in airway diseases. This is partially regulated by p38 mitogen-activated protein kinase (MAPK), which further activates two closely related isoforms of the MAPK-activated protein kinases (MKs), MK2 and MK3. The MKs have similar substrate specificities but less is known about differences in their functional responses. This study was undertaken to identify differential downstream inflammatory targets of MK2 and MK3 signaling and assess cross-talk between the MAPK pathway and NF-κB signaling relevant to ASM function.

Authors : Ba Mariam , Rawat Shanti , Lao Ronna , Grous Marilyn , Salmon Michael , Halayko Andrew J , Gerthoffer William T , Singer Cherie A ,

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