Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :30216105
Publication Date : //

Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques.


1. Glutathione S-transferase (GST) is a family of enzymes important for conjugation with glutathione of endogenous and exogenous compounds. Human GSTM1 null allele is associated with toxicity and cancers. Cynomolgus and rhesus macaques have molecular and enzymatic similarities of GSTs to humans; however, genetic variants have not been investigated. In macaques, instead of pseudogenized GSTM1, GSTM5 is a predominant GSTM isoform. 2. In this study, resequencing of GSTM5 in 64 cynomolgus and 31 rhesus macaques found 6 non-synonymous variants, and 1 variant (IVS5 + 1) causing exon skip. Of these 7 variants, 3 and 1 were found only in Indochinese and Indonesian cynomolgus macaques, respectively. 3. Cynomolgus GSTM5-mediated styrene 7,8-oxide and trans-stilbene oxide conjugation activities correlated with GSTM protein levels immunochemically quantified in cynomolgus liver samples. Using recombinant GSTM5 proteins, 4 of the 6 non-synonymous variants including E29Q, L96R, M166V, and S201N showed substantially lower metabolic activities. Moreover, a homozygote for E29Q and heterozygotes for S201N or IVS5 + 1 showed significantly lower conjugation activities in liver cytosolic fractions as compared with wild-type animals. 4. Therefore, the present results suggest that inter-animal variability of GST-dependent drug metabolism is at least partly accounted for by GSTM5 variants in cynomolgus and rhesus macaques as preclinical animal models.

Authors : Uno Yasuhiro , Murayama Norie , Tamura Kazuaki , Yamazaki Hiroshi ,

Related products :

Catalog number Product name Quantity
GSTO2 GSTM5 Gene glutathione S-transferase mu 5
201-20-2417 GSTM5{glutathione S-transferase M5}rabbit.pAb 0.2ml
CSB-EL009985RA Rat Glutathione S-transferase Mu 5(GSTM5) ELISA kit 96T
CSB-EL009985HU Human Glutathione S-transferase Mu 5(GSTM5) ELISA kit 96T
CSB-EL009985MO Mouse Glutathione S-transferase Mu 5(GSTM5) ELISA kit 96T
CSB-EL009985RA Rat Glutathione S-transferase Mu 5(GSTM5) ELISA kit SpeciesRat 96T
GSTM5 GSTM3 Gene glutathione S-transferase mu 3 (brain)
CSB-EL009985MO Mouse Glutathione S-transferase Mu 5(GSTM5) ELISA kit SpeciesMouse 96T
CSB-EL009985HU Human Glutathione S-transferase Mu 5(GSTM5) ELISA kit SpeciesHuman 96T
GSTM5_MOUSE ELISA Kit FOR Glutathione S-transferase Mu 5; organism: Mouse; gene name: Gstm5 96T
CSB-EL009985RA Rat glutathione S-transferase mu 5 (GSTM5) ELISA kit, Species Rat, Sample Type serum, plasma 96T
U0609m CLIA Glutathione S-transferase A1,Glutathione S-transferase Ya,Glutathione S-transferase Ya1,GST class-alpha member 1,Gsta,Gsta1,Gstya,Mouse,Mus musculus 96T
E0609m ELISA Glutathione S-transferase A1,Glutathione S-transferase Ya,Glutathione S-transferase Ya1,GST class-alpha member 1,Gsta,Gsta1,Gstya,Mouse,Mus musculus 96T
E0609m ELISA kit Glutathione S-transferase A1,Glutathione S-transferase Ya,Glutathione S-transferase Ya1,GST class-alpha member 1,Gsta,Gsta1,Gstya,Mouse,Mus musculus 96T
E0609m ELISA Glutathione S-transferase A3,Glutathione S-transferase Ya3,Glutathione S-transferase Yc,GST class-alpha member 3,Gsta3,Gstyc,Mouse,Mus musculus 96T
E0609m ELISA kit Glutathione S-transferase A3,Glutathione S-transferase Ya3,Glutathione S-transferase Yc,GST class-alpha member 3,Gsta3,Gstyc,Mouse,Mus musculus 96T
U0609m CLIA Glutathione S-transferase A3,Glutathione S-transferase Ya3,Glutathione S-transferase Yc,GST class-alpha member 3,Gsta3,Gstyc,Mouse,Mus musculus 96T
CSB-EL009985MO Mouse glutathione S-transferase mu 5 (GSTM5) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL009985HU Human glutathione S-transferase mu 5 (GSTM5) ELISA kit, Species Human, Sample Type serum, plasma 96T
E0609h ELISA Glutathione S-transferase A4,Glutathione S-transferase A4-4,GST class-alpha member 4,GSTA4,Homo sapiens,Human 96T
E0609h ELISA kit Glutathione S-transferase A4,Glutathione S-transferase A4-4,GST class-alpha member 4,GSTA4,Homo sapiens,Human 96T
E0609h ELISA Glutathione S-transferase A3,Glutathione S-transferase A3-3,GST class-alpha member 3,GSTA3,Homo sapiens,Human 96T
E0609m ELISA Glutathione S-transferase A2,Glutathione S-transferase GT41A,GST class-alpha member 2,Gsta2,Mouse,Mus musculus 96T
U0609h CLIA Glutathione S-transferase A5,Glutathione S-transferase A5-5,GST class-alpha member 5,GSTA5,Homo sapiens,Human 96T
U0609h CLIA Glutathione S-transferase A3,Glutathione S-transferase A3-3,GST class-alpha member 3,GSTA3,Homo sapiens,Human 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur