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Pubmed ID :30220711
Publication Date : //

Excessive tensile strain induced the change in chondrocyte phenotype.


Chondrocyte extracellular matrix type II collagen and proteoglycans ensure an important compression-bearing structure in synovial joint. However, much more type I collagen is generated in osteoarthritis, which implies the presence of abnormal tensile strain in cartilage. We hypothesize that tensile stress influences chondrocyte phenotype at the cellular level, leading to potential osteoarthritis.

Authors : Zhong Dongyan , Chen X I , Zhang Wen , Luo Zong-Ping ,

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