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Pubmed ID :30230404
Publication Date : //

Impaired copper transport in schizophrenia results in a copper-deficient brain state: a new side to the dysbindin story.


Several schizophrenia brain regions exhibit decreased dysbindin. Dysbindin modulates copper transport crucial for myelination, monoamine metabolism, and cellular homeostasis. Schizophrenia patients (SZP) exhibit increased plasma copper, while copper-decreasing agents produce schizophrenia-like behavioral and pathological abnormalities. Therefore, we sought to determine dysbindin and copper transporter protein expression and copper content in SZP. We studied the copper-rich substantia nigra (SN) using Western blot and inductively-coupled plasma mass spectrometry. We characterized specific protein domains of copper transporters ATP7A, CTR1, ATP7B, and dysbindin isoforms 1A and 1B/C in SZP (n = 15) and matched controls (n = 11), and SN copper content in SZP (n = 14) and matched controls (n = 11). As a preliminary investigation, we compared medicated (ON; n = 11) versus unmedicated SZP (OFF; n = 4). SZP exhibited increased C-terminus, but not N-terminus, ATP7A. SZP expressed less transmembrane CTR1 and dysbindin 1B/C than controls. ON exhibited increased C-terminus ATP7A protein versus controls. OFF exhibited less N-terminus ATP7A protein than controls and ON, suggesting medication-induced rescue of the ATP7A N-terminus. SZP exhibited less SN copper content than controls. These results provide the first evidence of disrupted copper transport in schizophrenia SN that appears to result in a copper-deficient state. Furthermore, copper homeostasis may be modulated by specific dysbindin isoforms and antipsychotic treatment.

Authors : Schoonover Kirsten E , Queern Stacy L , Lapi Suzanne E , Roberts Rosalinda C ,

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