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Pubmed ID :30231922
Publication Date : //

HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways.


Cartilage oligomeric matrix protein (COMP) is known to promote fibrosis in skin, lung and liver. Emerging evidence shows that COMP plays critical roles in tumor development, including breast cancer, colon cancer and hepatocellular carcinoma (HCC). Nevertheless, the role of COMP in HCC proliferation and metastasis and its underlying mechanisms remain fully unclear.

Authors : Li Qing , Wang Cong , Wang Yufeng , Sun Liankang , Liu Zhikui , Wang Liang , Song Tao , Yao Yingmin , Liu Qingguang , Tu Kangsheng ,

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