Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :30275759
Publication Date : //

Mitochondrial NADH Dehydrogenase Subunit 3 () Polymorphisms are Associated with Gastric Cancer Susceptibility.


Accumulating evidence indicates that mitochondrial DNA alterations contribute to cancer development and progression. In this study, we evaluated the relationship between polymorphisms of mitochondrial NADH dehydrogenase subunit 3 () and the risk of gastric cancer (GC). Five single nucleotide polymorphisms (SNPs; rs28358278, rs2853826, rs201397417, rs41467651, and rs28358275) were identified and genotyped in 377 patients with GC patients and 363 controls by direct sequencing. The rs41467651 T allele was significantly associated with GC risk [adjusted odds ratio (OR) = 2.11, 95% confidence interval (CI) = 1.25-3.55, = 0.005). In stratified analysis, rs28358278, rs2853826, and rs41467651 were associated with subgroups of GC, with the rs28358278 G, rs2853826 T, and rs41467651 T alleles associated with an increased GC risk in females (adjusted OR = 1.70, 95% CI = 1.08-2.69, = 0.023; adjusted OR = 1.78, 95% CI = 1.11-2.85, = 0.016; adjusted OR = 2.07, 95% CI = 1.04-4.12, = 0.038, respectively). The rs441467651 T allele was also related with GC risk in diffuse-type subjects compared to that of controls (adjusted OR = 2.61, 95% CI = 1.43-4.89, = 0.002). In addition, The rs441467651 T allele was significantly related with increased GC risk regardless of lymph node metastasis (LNM), T classification, and tumor stage compared to that of controls (adjusted OR = 2.00, 95% CI = 1.12-3.55, = 0.019 in LNM-negative subjects; adjusted OR = 2.10, 95% CI = 1.05-4.22, = 0.0379 in LNM-positive subjects; adjusted OR = 1.82, 95% CI = 1.02-3.24, = 0.042 in T1/T2 subjects; adjusted OR = 2.60, 95% CI = 1.29-5.24, = 0.007 in T3/T4 subjects; adjusted OR = 1.91, 95% CI = 1.09-3.34, = 0.025 in tumor stage I (A+B)/II (A+B+C) subjects; adjusted OR = 2.36, 95% CI = 1.12-5.13, = 0.025 in tumor stage III (A+B+C) subjects) compared to that of controls. Our findings suggest that the rs28358278, rs2853826, and rs41467651 polymorphisms of increase the susceptibility to GC development.

Authors : Jin Eun-Heui , Sung Jae Kyu , Lee Sang-Il , Hong Jang Hee ,

Related products :

Catalog number Product name Quantity
EIAAB26818 Bos taurus,Bovine,NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial,NADH dehydrogenase subunit II,NADH-ubiquinone oxidoreductase 24 kDa subunit,NDUFV2
EIAAB26811 CI-51kD,Complex I-51kD,Homo sapiens,Human,NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial,NADH dehydrogenase flavoprotein 1,NADH-ubiquinone oxidoreductase 51 kDa subunit,NDUFV1,UQOR1
EIAAB26813 Bos taurus,Bovine,CI-51kD,Complex I-51kD,NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial,NADH dehydrogenase flavoprotein 1,NADH-ubiquinone oxidoreductase 51 kDa subunit,NDUFV1,UQOR1
EIAAB26772 CI-B14.5b,Complex I-B14.5b,HLC1,HLC-1,Homo sapiens,Human,Human lung cancer oncogene 1 protein,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH-ubiquinone oxidoreductase subunit B14.5b,NDUFC2
EIAAB26806 Bos taurus,Bovine,CI-20kD,Complex I-20kD,NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial,NADH-ubiquinone oxidoreductase 20 kDa subunit,NDUFS7,PSST subunit
EIAAB26809 Bos taurus,Bovine,CI-23kD,Complex I-23kD,NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial,NADH-ubiquinone oxidoreductase 23 kDa subunit,NDUFS8,TYKY subunit
EIAAB26716 CI-39kD,Complex I-39kD,Homo sapiens,Human,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial,NADH-ubiquinone oxidoreductase 39 kDa subunit,NDUFA9,NDUFS2L
EIAAB26723 CI-42kD,Complex I-42kD,Homo sapiens,Human,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH-ubiquinone oxidoreductase 42 kDa subunit,NDUFA10
EIAAB26807 CI-20kD,Complex I-20kD,Homo sapiens,Human,NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial,NADH-ubiquinone oxidoreductase 20 kDa subunit,NDUFS7,PSST subunit
EIAAB26808 CI-23kD,Complex I-23kD,Homo sapiens,Human,NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial,NADH-ubiquinone oxidoreductase 23 kDa subunit,NDUFS8,TYKY subunit
EIAAB26719 CI-39kD,Complex I-39kD,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial,NADH-ubiquinone oxidoreductase 39 kDa subunit,Ndufa9,Rat,Rattus norvegicus,Sperm flagella protein 3
EIAAB26721 CI-42kD,Complex I-42kD,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH-ubiquinone oxidoreductase 42 kDa subunit,Ndufa10,Rat,Rattus norvegicus
EIAAB26724 CI-42kD,Complex I-42kD,Mouse,Mus musculus,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH-ubiquinone oxidoreductase 42 kDa subunit,Ndufa10
EIAAB26718 CI-39kD,Complex I-39kD,Mouse,Mus musculus,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial,NADH-ubiquinone oxidoreductase 39 kDa subunit,Ndufa9
EIAAB26717 Bos taurus,Bovine,CI-39kD,Complex I-39kD,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial,NADH-ubiquinone oxidoreductase 39 kDa subunit,NDUFA9
EIAAB26722 Bos taurus,Bovine,CI-42kD,Complex I-42kD,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH-ubiquinone oxidoreductase 42 kDa subunit,NDUFA10
EIAAB26815 Mouse,Mus musculus,NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial,NADH-ubiquinone oxidoreductase 24 kDa subunit,Ndufv2
EIAAB26814 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial,NADH-ubiquinone oxidoreductase 24 kDa subunit,Ndufv2,Rat,Rattus norvegicus
EIAAB26822 CI-9kD,Complex I-9kD,NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial,NADH-ubiquinone oxidoreductase 9 kDa subunit,Ndufv3,Rat,Rattus norvegicus
EIAAB26820 Bos taurus,Bovine,CI-9kD,Complex I-9kD,NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial,NADH-ubiquinone oxidoreductase 9 kDa subunit,NDUFV3
EIAAB26816 Homo sapiens,Human,NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial,NADH-ubiquinone oxidoreductase 24 kDa subunit,NDUFV2
EIAAB26819 CI-9kD,Complex I-9kD,Mouse,Mus musculus,NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial,NADH-ubiquinone oxidoreductase 9 kDa subunit,Ndufv3
EIAAB26768 CI-ESSS,Complex I-ESSS,Mouse,Mus musculus,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial,NADH-ubiquinone oxidoreductase ESSS subunit,Ndufb11,Neuronal protein 15.6,Np15,Np1
EIAAB26767 CI-ESSS,Complex I-ESSS,Homo sapiens,Human,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial,NADH-ubiquinone oxidoreductase ESSS subunit,NDUFB11,Neuronal protein 17.3,Np17.3,p
EIAAB26738 CI-AGGG,Complex I-AGGG,Homo sapiens,Human,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial,NADH-ubiquinone oxidoreductase AGGG subunit,NDUFB2


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur