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Pubmed ID :30308458
Publication Date : //

Melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (afmk) enhance chemosensitivity to gemcitabine in pancreatic carcinoma cells (PANC-1).


Gemcitabine is a standard chemotherapeutic agent for patients suffering from pancreatic cancer. However, the applied therapy is not effective due to the resistance of tumor cells to cytostatics, caused by inefficiency of the apoptotic mechanisms. Herein, we present the hypothesis that melatonin and its metabolite N-acetyl-N-formyl-5-methoxykynuramine (AFMK) modify the effect of gemcitabine on PANC-1 cells and that this phenomenon is dependent on the modulation of apoptosis.

Authors : Leja-Szpak Anna , Nawrot-Porąbka Katarzyna , Góralska Marta , Jastrzębska Martyna , Link-Lenczowski Paweł , Bonior Joanna , Pierzchalski Piotr , Jaworek Jolanta ,

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