Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :30341184
Publication Date : //

Targeted Diet Modification Reduces Multiple Sclerosis-like Disease in Adult Marmoset Monkeys from an Outbred Colony.


Experimental autoimmune encephalomyelitis (EAE) in common marmosets is a translationally relevant model of the chronic neurologic disease multiple sclerosis. Following the introduction of a new dietary supplement in our purpose-bred marmoset colony, the percentage of marmosets in which clinically evident EAE could be induced by sensitization against recombinant human myelin oligodendrocyte glycoprotein in IFA decreased from 100 to 65%. The reduced EAE susceptibility after the dietary change coincided with reduced expression in the colony, an EBV-related γ1-herpesvirus associated with EAE. We then investigated, in a controlled study in marmoset twins, which disease-relevant parameters were affected by the dietary change. The selected twins had been raised on the new diet for at least 12 mo prior to the study. In twin siblings reverted to the original diet 8 wk prior to EAE induction, 100% disease prevalence (eight out of eight) was restored, whereas in siblings remaining on the new diet the EAE prevalence was 75% (six out of eight). Spinal cord demyelination, a classical hallmark of the disease, was significantly lower in new-diet monkeys than in monkeys reverted to the original diet. In new-diet monkeys, the proinflammatory T cell response to recombinant human myelin oligodendrocyte glycoprotein was significantly reduced, and RNA-sequencing revealed reduced apoptosis and enhanced myelination in the brain. Systematic typing of the marmoset gut microbiota using 16S rRNA sequencing demonstrated a unique, Bifidobacteria-dominated composition, which changed after disease induction. In conclusion, targeted dietary intervention exerts positive effects on EAE-related parameters in multiple compartments of the marmoset's gut-immune-CNS axis.

Authors : Kap Yolanda S , Bus-Spoor Carien , van Driel Nikki , Dubbelaar Marissa L , Grit Corien , Kooistra Susanne M , Fagrouch Zahra C , Verschoor Ernst J , Bauer Jan , Eggen Bart J L , Harmsen Hermie J M , Laman Jon D , 't Hart Bert A ,

Related products :

Catalog number Product name Quantity
37-057-230168 Multiple Sclerosis Disease Brain 1 mg
37-057-232627 Multiple Sclerosis Disease Brain 5 Slides
37-057-232109 Multiple Sclerosis Disease Brain 5 Slides
C1236035Msc cDNA - Multiple Sclerosis Disease: Brain 40 rxn
37-057-232630 Multiple Sclerosis Disease Brain Amygdala 5 Slides
37-057-232170 Multiple Sclerosis Disease Brain Thalamus 5 Slides
37-057-232152 Multiple Sclerosis Disease Brain Pons 5 Slides
37-057-232149 Multiple Sclerosis Disease Brain Pituitary 5 Slides
37-057-232685 Multiple Sclerosis Disease Brain Thalamus 5 Slides
C1236035Msc cDNA _ Multiple Sclerosis Disease Brain 40 rxn
37-057-232115 Multiple Sclerosis Disease Brain Cerebellum 5 Slides
37-057-232112 Multiple Sclerosis Disease Brain Amygdala 5 Slides
37-057-230222 Multiple Sclerosis Disease Brain Thalamus 1 mg
C1236035Msc cDNA _ Multiple Sclerosis Disease Brain 40 rxn
37-057-230174 Multiple Sclerosis Disease Brain Cerebellum 1 mg
37-057-230171 Multiple Sclerosis Disease Brain Amygdala 1 mg
37-057-232633 Multiple Sclerosis Disease Brain Cerebellum 5 Slides
37-057-230204 Multiple Sclerosis Disease Brain Pons 1 mg
37-057-232648 Multiple Sclerosis Disease Brain Hippocampus 5 Slides
NB820-59394 Multiple Sclerosis Disease Brain 1 mg
37-057-232667 Multiple Sclerosis Disease Brain Pons 5 Slides
37-057-232130 Multiple Sclerosis Disease Brain Hippocampus 5 Slides
C1236036Msc cDNA _ Multiple Sclerosis Disease Brain Amygdala 40 rxn
37-057-232657 Multiple Sclerosis Disease Brain Occipital Lobe 5 Slides
C1236079Msc cDNA _ Multiple Sclerosis Disease Brain Thalamus 40 rxn


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur