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Pubmed ID :30368741
Publication Date : //

Advanced glycation end products are elevated in estrogen receptor-positive breast cancer patients, alter response to therapy, and can be targeted by lifestyle intervention.


Lifestyle factors associated with personal behavior can alter tumor-associated biological pathways and thereby increase cancer risk, growth, and disease recurrence. Advanced glycation end products (AGEs) are reactive metabolites produced endogenously as a by-product of normal metabolism. A Western lifestyle also promotes AGE accumulation in the body which is associated with disease phenotypes through modification of the genome, protein crosslinking/dysfunction, and aberrant cell signaling. Given the links between lifestyle, AGEs, and disease, we examined the association between dietary-AGEs and breast cancer.

Authors : Walter Katherine R , Ford Marvella E , Gregoski Mathew J , Kramer Rita M , Knight Kendrea D , Spruill Laura , Nogueira Lourdes M , Krisanits Bradley A , Phan Van , La Rue Amanda C , Lilly Michael B , Ambs Stefan , Chan King , Turner Tonya F , Varner Heidi , Singh Shweta , Uribarri Jaime , Garrett-Mayer Elizabeth , Armeson Kent E , Hilton Ebony J , Clair Mark J , Taylor Marian H , Abbott Andrea M , Findlay Victoria J , Peterson Lindsay L , Magwood Gayenell , Turner David P ,

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