Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :30395996
Publication Date : //

Chlorine dioxide inhibits the replication of porcine reproductive and respiratory syndrome virus by blocking viral attachment.


Porcine reproductive and respiratory syndrome virus (PRRSV) causes a great economic loss to the swine industry globally. Current prevention and treatment measures are not effective to control the outbreak and spread of porcine reproductive and respiratory syndrome (PRRS). In other words, new antiviral strategies are urgently needed. Chlorine dioxide (ClO) is regarded as a broad-spectrum disinfectant with strong inhibitory effects on microbes and parasites. The purpose of this study was to evaluate the inhibitory effects and underlying molecular mechanisms of ClO against PRRSV infection in vitro. Here, we identified ClO (the purity is 99%) could inhibit the infection and replication of PRRSV in both Marc-145 cells and porcine alveolar macrophages (PAMs). ClO could block PRRSV binding to cells rather than internalization and release, suggesting that ClO blocks the first stage of the virus life cycle. We also demonstrated that the inhibition exerted by ClO was attributed to the degradation of PRRSV genome and proteins. Moreover, we confirmed that ClO could decrease the expression of inflammatory cytokines induced by PRRSV. In summary, ClO is an efficient agent and potently suppressed PRRSV infection in vitro.

Authors : Zhu Zhenbang , Guo Yang , Yu Piao , Wang Xiaoying , Zhang Xiaoxiao , Dong Wenjuan , Liu Xiaohong , Guo Chunhe ,

Related products :

Catalog number Product name Quantity
K 042 PRRSV (porcine reproductive and respiratory syndrome virus) 100 reactions
FR036 Porcine reproductive and respiratory syndrome virus 100
KA2120 Porcine Reproductive and Respiratory Syndrome Virus ELISA Kit 1 Kit
K042 PRRSV (porcine reproductive and respiratory syndrome virus) 100
VET-S001-96R Porcine reproductive and Respiratory syndrome virus PCR detection kit, Porcine, RNA 96rxs
VET-S001-96R Porcine reproductive and Respiratory syndrome virus PCR detection kit, Porcine, RNA 48rxs
K042 PRRSV (porcine reproductive and respiratory syndrome virus) conventional PCR 100 REACTIONS
K042 PRRSV (porcine reproductive and respiratory syndrome virus) , RNA - VIRUSES, conventional PCR 100 REACTIONS
FR036 Porcine reproductive and respiratory syndrome virus FLUORGENIC REALTIME PCR - READY TO USE KIT 100 REACTIONS
AE-200180-2 Porcine reproductive and respiratory syndrome virus (PRRSV) Antibody ELISA kit, 2x96 tests 1 Kit
FR036 Porcine reproductive and respiratory syndrome virus ,FLUORGENIC REALTIME PCR - READY TO USE KITS, REAL TIME PCR 100 REACTIONS
AR-0103-03 Porcine Reproductive and Respiratory Syndrome (PRRSV) PCR Kit RNA PCR Instrument 25
AR-0103-01 Porcine Reproductive and Respiratory Syndrome (PRRSV) Real Time PCR Kit RNA I, II 25
AR-0103-02 Porcine Reproductive and Respiratory Syndrome (PRRSV) Real Time PCR Kit RNA III 25
AR-0103-03 Porcine Reproductive and Respiratory Syndrome (PRRSV) RT_PCR Kit PCR Instrument *to see for appropriate equipment see catalogue No. MXX_000069 25
YV0165-05 Reproductive and Respiratory Syndrome Virus (nucleocapsid), Swine, Clone 2D6, Mab anti_, Ascites 0.5 mg.
YV0165-01 Reproductive and Respiratory Syndrome Virus (nucleocapsid), Swine, Clone 2D6, Mab anti_, Ascites 0.1 mg.
AR-0103-02 Porcine Reproductive and Respiratory Syndrome (PRRSV) Real Time RT_PCR Kit III, IV *to see for appropriate equipment see catalogue No. MXX_000069 25
AR-0103-01 Porcine Reproductive and Respiratory Syndrome (PRRSV) Real Time RT_PCR Kit I, II *to see for appropriate equipment see catalogue No. MXX_000069 25
CSB-EQ027198PI Pig reproductive and respiratory syndrome virus(PRRSV)antibody(IgG)ELISA kit, Species , Sample Type 192T
CSB-EQ027198PI Pig reproductive and respiratory syndrome virus(PRRSV)antibody(IgG)ELISA kit, Species Pig, Sample Type serum, plasma 96T
G7268 Reproductive and respiratory syndrome virus (PRRSV)antibody (IgG)ELISA kit, Pig, ELISA Kit 96T
IP15037 Porcine repoductive & respiratory syndrome virus (PRRS, EU & NA) 25 T
IP12526 Porcine repoductive & respiratory syndrome virus (PRRS) 48T
PIP018 NATIVE RESPIRATORY SYNCYTIAL VIRUS , Product Type Antigen, Specificity RESPIRATORY SYNCYTIAL VIRUS, Target Species Viral, Host N_A, Format Inactivated Pathogen, Isotypes , Applications E, Clone 1 ml


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur