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Pubmed ID :30411300
Publication Date : //

Hepatic Cytochrome P450 Activity and Nitric Oxide Production During Multiple Ovalbumin Challenges.


Mast cell-mediated allergic diseases are a significant global health problem. Nitric oxide (NO) produced by acute type 1 allergies greatly suppresses hepatic cytochrome P450 (CYP) metabolism. A recent in vitro study demonstrated that repeated FcεRI-mediated activation intrinsically modulates mast cell function. We investigated the effect of ovalbumin (OVA) challenges on CYP activity and NO production under real immune responses.

Authors : Tanino Tadatoshi , Bando Toru , Okada Yuna , Nojiri Yukie , Hashimoto Kanako , Ueda Yukari , Sakurai Eiichi ,

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