Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :7521920
Publication Date : //

Dual tropism for macrophages and lymphocytes is a common feature of primary human immunodeficiency virus type 1 and 2 isolates.


We have investigated the ability of human immunodeficiency virus type 1 (HIV-1) and HIV-2 isolates to infect and replicate in primary human macrophages. Monocytes from blood donors were allowed to differentiate into macrophages by culture in the presence of autologous lymphocytes and human serum for 5 days before infection. A panel of 70 HIV-1 and 12 HIV-2 isolates were recovered from seropositive individuals with different severities of HIV infection. A majority of isolates (55 HIV-1 and all HIV-2) were obtained from peripheral blood mononuclear cells, but isolates from cerebrospinal fluid, monocytes, brain tissue, plasma, and purified CD4+ lymphocytes were also included. All isolates were able to infect monocyte-derived macrophages, even though the replicative capacity of the isolates varied. Interestingly, isolates with a rapid/high, syncytium-inducing phenotype did not differ from slow/low, non-syncytium-inducing isolates in their ability to replicate in monocyte-derived macrophages. Others have reported that rapid/high, syncytium-inducing isolates have a reduced ability to infect and replicate in monocytes. However, different methods to isolate and culture the monocytes/macrophages were used in these studies and our study. Thus, the ability of HIV isolates to replicate in monocytes/macrophages appears to be strongly influenced by the isolation and culture procedures. It remains to be determined which culture procedure is more relevant for the in vivo situation.

Authors : Valentin A , Albert J , Fenyö E M , Asjö B ,

Related products :

Catalog number Product name Quantity
OBT0823 MOUSE ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 p17, Product Type Monoclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 p17, Target Species Viral, Host Mouse, Format Purified, Isotypes IgG1, 0.1 mg
SCH-4999-9157 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 p24 HRP, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 p24, Target Species Viral, Host Goat, Format HRP, Isotypes Polyclon 1 ml
4999-9157 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 p24 HRP, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 p24, Target Species Viral, Host Goat, Format HRP, Isotypes Polyclon 1 ml
SCH-OBT0823 MOUSE ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 p17, Product Type Monoclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 p17, Target Species Viral, Host Mouse, Format Purified, Isotypes IgG1, 0.1 mg
ODN006-1 ODNBW006 Type B CpG ODN structure feature at the 5' and A-type CpG ODN structure feature at the 3' end Species Reactivity: 1 mg Product tipe: ODNs/DNAs
SCH-4999-8607 MOUSE ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 p24, Product Type Monoclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 p24, Target Species Viral, Host Mouse, Format Purified, Isotypes IgG1, 0.1 mg
SCH-4999-9007 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 p24, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 p24, Target Species Viral, Host Goat, Format Purified, Isotypes Polyclo 1 ml
4999-8607 MOUSE ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 p24, Product Type Monoclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 p24, Target Species Viral, Host Mouse, Format Purified, Isotypes IgG1, 0.1 mg
4999-9007 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 p24, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 p24, Target Species Viral, Host Goat, Format Purified, Isotypes Polyclo 1 ml
SCH-5000-0557 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 gp120, Target Species Viral, Host Goat, Format Purified, Isotypes Polyclona 1 ml
5000-0557 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 gp120, Target Species Viral, Host Goat, Format Purified, Isotypes Polyclona 1 ml
4999-8204 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 HRP, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1, Target Species Viral, Host Goat, Format HRP, Isotypes Polyclonal IgG, 1 ml
SCH-4999-8204 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 HRP, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1, Target Species Viral, Host Goat, Format HRP, Isotypes Polyclonal IgG, 1 ml
SCH-4999-8004 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1, Target Species Viral, Host Goat, Format Purified, Isotypes Polyclonal IgG, 1 ml
4999-8004 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1, Target Species Viral, Host Goat, Format Purified, Isotypes Polyclonal IgG, 1 ml
SCH-5000-0587 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 gp120 HRP, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 gp120, Target Species Viral, Host Goat, Format HRP, Isotypes Poly 1 ml
OBT0935 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 gp41, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 gp41, Target Species Viral, Host Goat, Format Purified, Isotypes Polyc 1 ml
SCH-OBT0935 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 gp41, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 gp41, Target Species Viral, Host Goat, Format Purified, Isotypes Polyc 1 ml
5000-0587 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 gp120 HRP, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 gp120, Target Species Viral, Host Goat, Format HRP, Isotypes Poly 1 ml
SCH-OBT1861 RECOMBINANT HUMAN IMMUNODEFICIENCY VIRUS 1 gag, Product Type Recombinant Protein, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 gag, Target Species Viral, Host N_A, Format Rec. Protein, Isotypes , 0.1 mg
OBT1861 RECOMBINANT HUMAN IMMUNODEFICIENCY VIRUS 1 gag, Product Type Recombinant Protein, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 gag, Target Species Viral, Host N_A, Format Rec. Protein, Isotypes , 0.1 mg
OBT0935B GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 gp41 Biotin, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 gp41, Target Species Viral, Host Goat, Format Biotin, Isotypes 1 ml
SCH-OBT0935B GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 gp41 Biotin, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 gp41, Target Species Viral, Host Goat, Format Biotin, Isotypes 1 ml
5000-0567 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 gp120 Biotin, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 gp120, Target Species Viral, Host Goat, Format Biotin, Isotypes 1 ml
SCH-5000-0567 GOAT ANTI HUMAN IMMUNODEFICIENCY VIRUS 1 gp120 Biotin, Product Type Polyclonal Antibody, Specificity HUMAN IMMUNODEFICIENCY VIRUS 1 gp120, Target Species Viral, Host Goat, Format Biotin, Isotypes 1 ml


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur