Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :10424734
Publication Date : //

MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver.


Multidrug resistance-associated protein (MRP) and the canalicular multispecific organic anion transporter (cMOAT) are organic anion pumps that have been linked to cytotoxic drug resistance. We previously reported the isolation of three human MRP/cMOAT-related transporters, MOAT-B (MRP4), MOAT-C (MRP5) and MOAT-D (MRP3). In the present study we describe the fourth MRP/cMOAT-related transporter. We analysed ARA, a human cDNA reported to encode a 453 residue MRP-related transporter, and found that it represents a fused transcript composed of MRP sequences and partial sequences of a novel transporter. The complete coding sequence of this novel transporter, which we designated MOAT-E, was isolated. MOAT-E encodes a 1503 residue transporter that is most closely related to MRP (45%), MOAT-D (44%) and cMOAT (39%), both in terms of amino acid identity and sharing a common topology in which approximately 17 transmembrane spanning helices are distributed within three membrane spanning domains. RNA blot analysis indicated that MOAT-E expression is restricted to kidney and liver. These observations suggest that MOAT-E may function as an organic anion transporter involved in cellular detoxification and possibly in the hepatobiliary and renal excretion of xenobiotics and/or endogenous metabolites. Isolation of MOAT-E helps to define the MRP/cMOAT subfamily of transporters.

Authors : Belinsky M G , Kruh G D ,

Related products :

Catalog number Product name Quantity
EIAAB25433 ABCC4,ATP-binding cassette sub-family C member 4,Homo sapiens,Human,MOAT-B,MRP_cMOAT-related ABC transporter,MRP4,Multidrug resistance-associated protein 4,Multi-specific organic anion transporter B
27-666 The TSFM gene encodes a protein that is expressed in all tissues, with the highest levels of expression in skeletal muscle, liver, and kidney. 0.05 mg
20-272-191202 MRP4 - Rat monoclonal [M4I - 10] to MRP4; ATP-binding cassette sub-family C member 4; MRP_cMOAT-related ABC transporter; Multi-specific organic anion transporter-B; MOAT-B Monoclonal 0.5 ml
20-272-191201 MRP4 - Rat monoclonal [M4I - 80] to MRP4; ATP-binding cassette sub-family C member 4; MRP_cMOAT-related ABC transporter; Multi-specific organic anion transporter-B; MOAT-B Monoclonal 0.1 mg
SMC-182D FIH, FIH162C Monoclonals AntibodiesFIH 162c Full length human FIH expressed in E.coli BL21 (DE3) cells 100ug
SMC-152C p38 alpha MAPKinase Monoclonals Antibodies9F12 Full length recombinant protein expressed in E.coli cells. 25ug
SMC-152D p38 alpha MAPKinase Monoclonals Antibodies9F12 Full length recombinant protein expressed in E.coli cells. 100ug
EIAAB36636 Kidney H(+)_peptide cotransporter,Oligopeptide transporter, kidney isoform,Pept2,Peptide transporter 2,Rat,Rattus norvegicus,Slc15a2,Solute carrier family 15 member 2
EIAAB36637 Kidney H(+)_peptide cotransporter,Mouse,Mus musculus,Oligopeptide transporter, kidney isoform,Pept2,Peptide transporter 2,Slc15a2,Solute carrier family 15 member 2
EIAAB36634 Kidney H(+)_peptide cotransporter,Oligopeptide transporter, kidney isoform,Oryctolagus cuniculus,PEPT2,Peptide transporter 2,Rabbit,SLC15A2,Solute carrier family 15 member 2
EIAAB36635 Homo sapiens,Human,Kidney H(+)_peptide cotransporter,Oligopeptide transporter, kidney isoform,PEPT2,Peptide transporter 2,SLC15A2,Solute carrier family 15 member 2
PR-890 Proteins: p53GST full length GST-tagged Tumor Protein p53 (full length)human, recombinant, E. coli 10
PR-890 p53GST full length GST-tagged Tumor Protein p53 (full length) human, recombinant, E. coli 10
29-580 Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb 0.1 mg
29-581 Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb 0.1 mg
SMC-182D FIH Antibody Monoclonal, Clone number: FIH 162c Host: Mouse, Isotype: IgG1 Immunogen: Full length human FIH expressed in E.coli BL21 (DE3) cells 100ug
SMC-152D p38 alpha (MAP Kinase) Antibody Monoclonal, Clone number: 9F12 Host: Mouse, Isotype: IgG1 Immunogen: Full length recombinant protein expressed in E.coli cells. 100ug
SMC-152C p38 alpha (MAP Kinase) Antibody Monoclonal, Clone number: 9F12 Host: Mouse, Isotype: IgG1 Immunogen: Full length recombinant protein expressed in E.coli cells. 25ug
orb90126 Glutathione S-Transferase His Tag protein Recombinant Schistosoma japonicum GST full length protein contains 244 amino acids(1-224 a.a.) expressed in E.coli, having a molecular mass of 28.3kDa. The GS 10
EIAAB36715 Kidney-specific transport protein,mNKT,Mouse,mROAT1,Mus musculus,Nkt,Novel kidney transcript,Oat1,Organic anion transporter 1,Renal organic anion transporter 1,Slc22a6,Solute carrier family 22 member
18-003-43987 Bone marrow macrophage cDNA. RIKEN full-length enriched library. clone I830005M14 product tumor susceptibility gene 101. full in - 17 days embryo heart cDNA. RIKEN full-length enriched library. clone 0.1 mg Protein A
18-003-44051 Bone marrow macrophage cDNA. RIKEN full-length enriched library. clone I830005M14 product tumor susceptibility gene 101. full in - 17 days embryo heart cDNA. RIKEN full-length enriched library. clone 0.1 mg Protein A
EIAAB25434 Abcc5,Abcc5a,ATP-binding cassette sub-family C member 5,MOAT-C,Mouse,Mrp5,Multidrug resistance-associated protein 5,Multi-specific organic anion transporter C,Mus musculus,SMRP
29-628 Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Bec 0.05 mg
EIAAB25435