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Pubmed ID :11114383
Publication Date : //

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.


A novel sequence discovered in a computational screen appears distantly related to the p35 subunit of IL-12. This factor, which we term p19, shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a novel, biologically active, composite cytokine, which we term IL-23. Activated dendritic cells secrete detectable levels of this complex. IL-23 binds to IL-12R beta 1 but fails to engage IL-12R beta 2; nonetheless, IL-23 activates Stat4 in PHA blast T cells. IL-23 induces strong proliferation of mouse memory (CD4(+)CD45Rb(low)) T cells, a unique activity of IL-23 as IL-12 has no effect on this cell population. Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells.

Authors : Oppmann B , Lesley R , Blom B , Timans J C , Xu Y , Hunte B , Vega F , Yu N , Wang J , Singh K , Zonin F , Vaisberg E , Churakova T , Liu M , Gorman D , Wagner J , Zurawski S , Liu Y , Abrams J S , Moore K W , Rennick D , de Waal-Malefyt R , Hannum C , Bazan J F , Kastelein R A ,

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