Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :11137014
Publication Date : //

FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis.

Huntington's disease is characterised by the death of cortical and striatal neurons, and is the result of an expanded polyglutamine tract in the Huntingtin protein [1]. Huntingtin is present on both endocytic and secretory membrane organelles but its function is unclear [2,3]. Rab GTPases regulate both of these transport pathways [4]. We have previously shown that Rab8 controls polarised membrane transport by modulating cell morphogenesis [5]. To understand Rab8-mediated processes, we searched for Rab8-interacting proteins by the yeast two-hybrid system. Here, we report that Huntingtin is linked to the Rab8 protein through FIP-2, a tumour necrosis factor-alpha (TNF-alpha)-inducible coiled-coil protein related to the NEMO protein [6,7]. The activated form of Rab8 interacted with the amino-terminal region of FIP-2, whereas dominant-negative Rab8 did not. Huntingtin bound to the carboxy-terminal region of FIP-2. Coexpressed FIP-2 and Huntingtin enhanced the recruitment of Huntingtin to Rab8-positive vesicular structures, and FIP-2 promoted cell polarisation in a similar way to Rab8. We propose a model in which Huntingtin, together with FIP-2 and Rab8, are part of a protein network that regulates membrane trafficking and cellular morphogenesis.

Authors : Hattula K , Peränen J ,

Related products :

Catalog number Product name Quantity
EIAAB05927 Ccdc40,Coiled-coil domain-containing protein 40,Lnks,Mouse,Mus musculus,Protein links
EIAAB07128 C9orf49,CHCHD2P9,CHCHD9,Coiled-coil-helix-coiled-coil-helix domain-containing 2 pseudogene 9,Homo sapiens,Human,Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitocho
EIAAB05061 Calcium-binding and coiled-coil domain-containing protein 1,Calcoco1,CocoA,Coiled-coil coactivator protein,Kiaa1536,Mouse,Mus musculus
EIAAB33921 Cc1,Coiled-coil-forming protein 1,Kiaa0203,LaXp180,Mouse,Mus musculus,Rb1cc1,RB1-inducible coiled-coil protein 1
EIAAB05058 Calcium-binding and coiled-coil domain-containing protein 1,CALCOCO1,Calphoglin,Coiled-coil coactivator protein,Homo sapiens,Human,KIAA1536,PP13275,Sarcoma antigen NY-SAR-3,UNQ2436_PRO4996
31-244 TAL-1 modulates the angiogenic response of endothelial cells by stimulating cell morphogenesis and by influencing their behavior in migration. 0.05 mg
EIAAB05742 Ccdc115,Ccp1,Coiled-coil domain-containing protein 115,Coiled-coil protein 1,Mouse,Mus musculus
EIAAB46890 CCDC131,Coiled-coil domain-containing protein 131,Homo sapiens,Human,KIAA0546,Proline_serine-rich coiled-coil protein 2,PSRC2,ZFC3H1,Zinc finger C3H1 domain-containing protein
EIAAB07114 AAG10,Aging-associated gene 10 protein,C7orf17,CHCHD2,Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial,HCV NS2 trans-regulated protein,Homo sapiens,Human,NS2TP
EIAAB06031 Ccdc86,Coiled-coil domain-containing protein 86,Cyclon,Cytokine-induced protein with coiled-coil domain,D19Ertd678e,mCyclon,MNCb-4327,Mouse,Mus musculus
EIAAB35678 Homo sapiens,Human,p160 ROCK-1,p160ROCK,Renal carcinoma antigen NY-REN-35,Rho-associated protein kinase 1,Rho-associated, coiled-coil-containing protein kinase 1,Rho-associated, coiled-coil-containing
EIAAB07126 CHCHD8,Coiled-coil-helix-coiled-coil-helix domain-containing protein 8,E2IG2,E2-induced gene 2 protein,Homo sapiens,Human
EIAAB07111 C22orf16,CHCHD10,Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial,Homo sapiens,Human,Protein N27C7-4
EIAAB11296 CCD1,Coiled-coil protein DIX1,Coiled-coil-DIX1,DIX domain-containing protein 1,DIXDC1,Dixin,Homo sapiens,Human,KIAA1735
EIAAB07113 C10orf34,CHCHD1,Coiled-coil-helix-coiled-coil-helix domain-containing protein 1,Homo sapiens,Human,Nuclear protein C2360
EIAAB05828 C6orf184,C6orf185,CCDC162,CCDC162P,Coiled-coil domain-containing protein 162,Coiled-coil domain-containing protein 162 pseudogene,Homo sapiens,Human
EIAAB11295 Ccd1,Coiled-coil protein DIX1,Coiled-coil-DIX1,DIX domain-containing protein 1,Dixdc1,Dixin,Kiaa1735,Mouse,Mus musculus
EIAAB06030 CCDC86,Coiled-coil domain-containing protein 86,CYCLON,Cytokine-induced protein with coiled-coil domain,Homo sapiens,Human
EIAAB11294 Ccd1,Coiled-coil protein DIX1,Coiled-coil-DIX1,DIX domain-containing protein 1,Dixdc1,Dixin,Rat,Rattus norvegicus
EIAAB25846 Homo sapiens,Human,MURC,Muscle-related coiled-coil protein,Muscle-restricted coiled-coil protein
EIAAB06029 Ccdc86,Coiled-coil domain-containing protein 86,Cyclon,Cytokine-induced protein with coiled-coil domain,Rat,Rattus norvegicus
EIAAB42989 Homo sapiens,Human,PNAS-10,PNAS-136,TMCC4,TMCO1,Transmembrane and coiled-coil domain-containing protein 1,Transmembrane and coiled-coil domains protein 4,UNQ151_PRO177,Xenogeneic cross-immune protein
CSB-EL005324HU Human Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial(CHCHD9) ELISA kit SpeciesHuman 96T
CSB-EL005324HU Human Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial(CHCHD9) ELISA kit 96T
G5255 Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial (CHCHD9), Human, ELISA Kit 96T


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur

Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur