Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :11780126
Publication Date : //

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.


Phosphorylation of p53 at Ser 46 was shown to regulate p53 apoptotic activity. Here we demonstrate that homeodomain-interacting protein kinase-2 (HIPK2), a member of a novel family of nuclear serine/threonine kinases, binds to and activates p53 by directly phosphorylating it at Ser 46. HIPK2 localizes with p53 and PML-3 into the nuclear bodies and is activated after irradiation with ultraviolet. Antisense inhibition of HIPK2 expression reduces the ultraviolet-induced apoptosis. Furthermore, HIPK2 and p53 cooperate in the activation of p53-dependent transcription and apoptotic pathways. These data define a new functional interaction between p53 and HIPK2 that results in the targeted subcellular localization of p53 and initiation of apoptosis.

Authors : D'Orazi Gabriella , Cecchinelli Barbara , Bruno Tiziana , Manni Isabella , Higashimoto Yuichiro , Saito Shin'ichi , Gostissa Monica , Coen Sabrina , Marchetti Alessandra , Del Sal Giannino , Piaggio Guilia , Fanciulli Maurizio , Appella Ettore , Soddu Silvia ,

Related products :

Catalog number Product name Quantity
E11859h Human Homeodomain Interacting Protein Kinase 3 ELI 96T
E11858h Human Homeodomain Interacting Protein Kinase 4 ELI 96T
E9717h Human Homeodomain Interacting Protein Kinase 1 ELI 96T
CSB-EL010369RA Rat Homeodomain-interacting protein kinase 3(HIPK3) ELISA kit 96T
HIRIP3 HIPK4 Gene homeodomain interacting protein kinase 4
HIRA HIPK3 Gene homeodomain interacting protein kinase 3
E15027m Mouse ELISA Kit FOR Homeodomain-interacting protein kinase 2 96T
E1349m Human ELISA Kit FOR Homeodomain-interacting protein kinase 1 96T
HIPK4 HIPK2 Gene homeodomain interacting protein kinase 2
E1002Ge Human ELISA Kit FOR Homeodomain-interacting protein kinase 4 96T
18-003-42247 Homeodomain-interacting protein kinase 2 - EC 2.7.11.1; hHIPk2 Polyclonal 0.05 mg Aff Pur
CSB-EL010367RA Rat Homeodomain-interacting protein kinase 1(HIPK1) ELISA kit 96T
CSB-EL010370RA Rat Homeodomain-interacting protein kinase 4(HIPK4) ELISA kit 96T
HIPK3 HIPK1 Gene homeodomain interacting protein kinase 1
CSB-EL010370MO Mouse Homeodomain-interacting protein kinase 4(HIPK4) ELISA kit 96T
CSB-EL010368MO Mouse Homeodomain-interacting protein kinase 2(HIPK2) ELISA kit 96T
CSB-EL010369HU Human Homeodomain-interacting protein kinase 3(HIPK3) ELISA kit 96T
CSB-EL010367RA Rat Homeodomain-interacting protein kinase 1(HIPK1) ELISA kit SpeciesRat 96T
CSB-EL010368HU Human Homeodomain-interacting protein kinase 2(HIPK2) ELISA kit 96T
CSB-EL010370RA Rat Homeodomain-interacting protein kinase 4(HIPK4) ELISA kit SpeciesRat 96T
CSB-EL010369RA Rat Homeodomain-interacting protein kinase 3(HIPK3) ELISA kit SpeciesRat 96T
CSB-EL010367HU Human Homeodomain-interacting protein kinase 1(HIPK1) ELISA kit 96T
GWB-49DE8C Anti- HIPK2 (homeodomain interacting protein kinase 2) Antibody
CSB-EL010370HU Human Homeodomain-interacting protein kinase 4(HIPK4) ELISA kit 96T
CSB-EL010369MO Mouse Homeodomain-interacting protein kinase 3(HIPK3) ELISA kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur