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ADAM15 is an adherens junction molecule whose surface expression can be driven by VE-cadherin.
ADAM15 belongs to the family of proteins containing disintegrin and metalloprotease domains (ADAM) that have been implicated in cell adhesion via integrin binding and shedding of cell surface molecules. Here we provide the first report on the localization of an ADAM in adherens junctions. We show that ADAM15 colocalizes with a cell adhesion molecule, vascular endothelial (VE)-cadherin, which mediates endothelial cell adherens junction formation. In contrast, the distribution of ADAM15 correlates poorly with the localization in cell contacts of one of its proposed ligands, the beta1-integrin. Furthermore, ADAM15 accumulation in cell-cell contacts is preceded by VE-cadherin-mediated adherens junction formation. To investigate the dependence of ADAM15 surface expression on adherens junction formation, we coexpressed VE-cadherin with ADAM15 and an ADAM15 green fluorescence protein (GFP) fusion protein in Chinese hamster ovary cells. VE-cadherin coexpression results in the translocation of ADAM15-GFP to the cell periphery. Analysis of cell surface levels of ADAM15 and ADAM15-GFP, with or without VE-cadherin coexpression, clearly demonstrates that VE-cadherin can drive surface expression of ADAM15. Our data suggest that ADAM15 may be a novel component of adherens junctions and thus could play a role in endothelial functions that are mediated by these cell contacts.
Authors : Ham Claire , Levkau Bodo , Raines Elaine W , Herren Barbara ,
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Pathways :
WP2272: Pathogenic Escherichia coli infection
WP1263: Mitochondrial Gene Expression
WP1301: Mitochondrial Gene Expression
WP1368: Mitochondrial Gene Expression
WP152: FGF signaling pathway
WP1793: Cell junction organization
WP1794: Cell surface interactions at the vascular wall
WP1820: Gap junction trafficking and regulation
WP1821: Gene Expression
WP1833: Integrin cell surface interactions
WP1963: The effect of Glucocorticoids on target gene expression
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2118: Arrhythmogenic right ventricular cardiomyopathy
WP391: Mitochondrial Gene Expression
WP566: canonical wnt - zebrafish
WP928: Mitochondrial Gene Expression
Related Genes :
[ADAM15 MDC15] Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
[Adam15 Mdc15] Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (AD56) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
[Adam15 Mdc15] Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (CRII-7) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
[ADAM15 CK820_G0045175] ADAM metallopeptidase domain 15 (ADAM15 isoform 11)
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[ADAM15] ADAM metallopeptidase domain 15
[HCK] Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
[SNX33 SH3PX3 SH3PXD3C SNX30] Sorting nexin-33 (SH3 and PX domain-containing protein 3)
[ADAM15] ADAM metallopeptidase domain 15
[GRB2 ASH] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[SH3PXD2A FISH KIAA0418 SH3MD1 TKS5] SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
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