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Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.
The human immunodeficiency virus-1 (HIV-1) Tat protein was previously reported to compete the association of PA28 regulator with the alpha rings of the 20S proteasome and to inhibit its peptidase activity. However, the distinct interaction sites within the proteasome complex remained to be determined. Here we show that HIV-1 Tat binds to alpha4 and alpha7, six beta subunits of the constitutive 20S proteasome and the interferon-gamma-inducible subunits beta2i and beta5i. A Tat-proteasome interaction can also be demonstrated in vivo and leads to inhibition of proteasomal activity. This indicates that Tat can modulate or interfere with cellular proteasome function by specific interaction with distinct proteasomal subunits.
Authors : Apcher G Sébastien , Heink Sylvia , Zantopf Daniela , Kloetzel Peter-M , Schmid Hans-P , Mayer R John , Krüger Elke ,
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Pathways :
WP1566: Citrate cycle (TCA cycle)
WP210: Cytoplasmic Ribosomal Proteins
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP1434: Osteopontin Signaling
WP1438: Influenza A virus infection
WP1531: Vitamin D synthesis
WP1571: EBV LMP1 signaling
WP1614: 1- and 2-Methylnaphthalene degradation
WP1655: Geraniol degradation
WP1835: Interferon alpha/beta signaling
WP1904: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP215: noncanonical wnt pathway
WP219: Cytoplasmic tRNA Synthetases
WP2199: Seed Development
WP2218: sGC
WP2359: Parkin-Ubiquitin Proteasomal System pathway
WP244: Alpha 6 Beta 4 signaling pathway
WP262: EBV LMP1 signaling
WP32: Translation Factors
WP433: tRNA Synthetases
WP537: Translation Factors
WP566: canonical wnt - zebrafish
WP1003: Ovarian Infertility Genes
WP1045: TGF-beta Receptor Signaling Pathway
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Bibliography :
[14550573] Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.
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