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Pubmed ID :14674694
Publication Date : //

Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner.


Human Aurora/Ipl1-related kinase 2 (Aurora-B) is a key regulator of mitosis. Here human proteasome alpha-subunit C8 (HC8) was identified to interact with the Aurora-B by yeast two-hybrid screen. This finding was confirmed by GST pull-down assays and immunoprecipitation experiments. The Aurora-B protein level increased in HeLa cells cultured with proteasome inhibitor ALLN. Our data suggest that Aurora-B might undergo degradation by binding to HC8 in a proteasome-dependent manner during mitosis.

Authors : Shu Fengjue , Guo Shuguang , Dang Yongjun , Qi Meiyan , Zhou Guangjin , Guo Zekun , Zhang Ying , Wu Chaoqun , Zhao Shouyuan , Yu Long ,

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