Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :14729065
Publication Date : //

Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals.


The interaction between phosphatidylserine and its receptor on phagocytic cells plays a critical role in the clearance of apoptotic bodies under normal physiological condition. A specific receptor for phosphatidylserine (PSR) has recently been identified by phage display and shown to mediate phosphatidylserine dependent phagocytosis. Here we show that the protein encoded by the PSR cDNA is localized in the nuclei through multiple nuclear localization signals. First, a fusion between PSR and GFP is localized in the nuclei of transfected cells, suggesting that PSR have intrinsic nuclear localization capability. Indeed, affinity-purified anti-PSR antibodies identified a 47 kDa protein species in cells transfected with untagged PSR and localized this protein in the nuclei by immunofluorescent confocal microscopy. In NIH3T3 cells, which express endogenous PSR mRNA, a similar 47 kDa species was detected and localized in the nuclei. Finally, multiple nuclear localization signals were identified in PSR sequence, each capable of targeting GFP to the nuclei. Together, these results suggest that PSR may serve a dual role both on the cell surface and in the nuclei.

Authors : Cui Ping , Qin Baoming , Liu Nan , Pan Guangjin , Pei Duanqing ,

Related products :

Catalog number Product name Quantity
27-697 HUEL includes the putative nuclear receptor interaction motif, nuclear localization and export signals, zinc finger, leucine zipper and acidic domains. HUEL is likely to be an evolutionarily conserved 0.05 mg
26-912 The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLS 0.05 mg
25-414 PLAG1 is a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the sali 0.05 mg
31-277 PLAG1 is a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the sali 0.05 mg
28-814 PLAG1 is a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the sali 0.05 mg
EIAAB37262 HACS1,Hematopoietic adaptor containing SH3 and SAM domains 1,Homo sapiens,Human,Nash1,SAM domain, SH3 domain and nuclear localization signals protein 1,SAM domain-containing protein SAMSN-1,SAMSN1,SH3
EIAAB37261 Mouse,Mus musculus,SAM domain, SH3 domain and nuclear localization signals protein 1,SAM domain-containing protein SAMSN-1,Samsn1,SH3 protein expressed in lymphocytes 2,SH3-lymphocyte protein 2,SLy2
28-111 Inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta. Increased nuclear factor-kappa 0.1 mg
CSB-EL020693HU Human SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL020693MO Mouse SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
25-631 The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosi 0.05 mg
SAMSN1 SAMSN1 Gene SAM domain, SH3 domain and nuclear localization signals 1
201-20-3834 NPLOC4{nuclear protein localization 4 homolog (S. cerevisiae)}rabbit.pAb 0.2ml
NPM2 NPLOC4 Gene nuclear protein localization 4 homolog (S. cerevisiae)
ABR_HUMAN Mouse ELISA Kit FOR Probable RNA polymerase II nuclear localization protein SLC7A6OS 96T
RN19A_HUMAN Mouse ELISA Kit FOR Probable RNA polymerase II nuclear localization protein SLC7A6OS 96T
E0078r Mouse ELISA Kit FOR Probable RNA polymerase II nuclear localization protein SLC7A6OS 96T
CSB-EL015995HU Human Nuclear protein localization protein 4 homolog(NPLOC4) ELISA kit 96T
CSB-EL015995RA Rat Nuclear protein localization protein 4 homolog(NPLOC4) ELISA kit SpeciesRat 96T
CSB-EL015995MO Mouse Nuclear protein localization protein 4 homolog(NPLOC4) ELISA kit 96T
CSB-EL015995RA Rat Nuclear protein localization protein 4 homolog(NPLOC4) ELISA kit 96T
NPL4_RAT ELISA Kit FOR Nuclear protein localization protein 4 homolog; organism: Rat; gene name: Nploc4 96T
CSB-EL015995MO Mouse Nuclear protein localization protein 4 homolog(NPLOC4) ELISA kit SpeciesMouse 96T
CSB-EL015995HU Human Nuclear protein localization protein 4 homolog(NPLOC4) ELISA kit SpeciesHuman 96T
NPL4_MOUSE ELISA Kit FOR Nuclear protein localization protein 4 homolog; organism: Mouse; gene name: Nploc4 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur