Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :15689497
Publication Date : //

The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.


Phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P(2)] is a key second messenger that regulates actin and membrane dynamics, as well as other cellular processes. Many of the effects of PtdIns(4,5)P(2) are mediated by binding to effector proteins that contain a pleckstrin homology (PH) domain. Here, we identify two novel effectors of PtdIns(4,5)P(2) in the budding yeast Saccharomyces cerevisiae: the PH domain containing protein Slm1 and its homolog Slm2. Slm1 and Slm2 serve redundant roles essential for cell growth and actin cytoskeleton polarization. Slm1 and Slm2 bind PtdIns(4,5)P(2) through their PH domains. In addition, Slm1 and Slm2 physically interact with Avo2 and Bit61, two components of the TORC2 signaling complex, which mediates Tor2 signaling to the actin cytoskeleton. Together, these interactions coordinately regulate Slm1 targeting to the plasma membrane. Our results thus identify two novel effectors of PtdIns(4,5)P(2) regulating cell growth and actin organization and suggest that Slm1 and Slm2 integrate inputs from the PtdIns(4,5)P(2) and TORC2 to modulate polarized actin assembly and growth.

Authors : Fadri Maria , Daquinag Alexes , Wang Shimei , Xue Tao , Kunz Jeannette ,

Related products :

Catalog number Product name Quantity
EIAAB31275 Evectin-1,Evt1,Mouse,Mus musculus,PH domain-containing family B member 1,PH domain-containing protein in retina 1,Phr1,PHRET1,Pleckstrin homology domain retinal protein 1,Pleckstrin homology domain-co
30-191 Proteins that contain formin homology (FH) domains, such as FHOD3, play a role in regulation of the actin cytoskeleton. 0.05 mg
30-789 CNN2, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. CNN2 could play a role in smooth muscle contraction and cell adhesi 0.05 mg
30-790 CNN2, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. CNN2 could play a role in smooth muscle contraction and cell adhesi 0.05 mg
27-412 EB1 family proteins are evolutionarily conserved proteins that bind microtubule plus-ends and centrosomes and regulate the dynamics and organization of microtubules. Human EB1 family proteins, which i 0.1 mg
orb81276 Human Pleckstrin Homology-Like Domain Family Member 2 protein Proteins 2
EIAAB14440 CDEP,Chondrocyte-derived ezrin-like protein,FARP1,FERM, RhoGEF and pleckstrin domain-containing protein 1,Homo sapiens,Human,PH domain-containing family C member 2,Pleckstrin homology domain-containin
EIAAB14441 FARP2,FERM domain including RhoGEF,FERM, RhoGEF and pleckstrin domain-containing protein 2,FIR,Homo sapiens,Human,KIAA0793,PH domain-containing family C member 3,Pleckstrin homology domain-containing
EIAAB31262 FAPP1,FAPP-1,Homo sapiens,Human,PH domain-containing family A member 3,Phosphatidylinositol-four-phosphate adapter protein 1,Phosphoinositol 4-phosphate adapter protein 1,Pleckstrin homology domain-co
EIAAB31273 Fapp2,FAPP-2,Mouse,Mus musculus,PH domain-containing family A member 8,Phosphatidylinositol-four-phosphate adapter protein 2,Phosphoinositol 4-phosphate adapter protein 2,Pleckstrin homology domain-co
EIAAB31263 Fapp1,FAPP-1,Mouse,Mus musculus,PH domain-containing family A member 3,Phosphatidylinositol-four-phosphate adapter protein 1,Phosphoinositol 4-phosphate adapter protein 1,Pleckstrin homology domain-co
27-092 SH3BP2 has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 a 0.05 mg
EIAAB31276 Evectin-1,EVT1,Homo sapiens,Human,KPL1,PH domain-containing family B member 1,PH domain-containing protein in retina 1,PHR1,PHRET1,PHRET1,Pleckstrin homology domain retinal protein 1,Pleckstrin homolo
EIAAB31330 Homo sapiens,Human,PH domain-containing family O member 2,PH domain-containing family Q member 1,Pleckstrin homology domain-containing family O member 2,Pleckstrin homology domain-containing family Q
pro-781 Recombinant Human Pleckstrin Homology-Like Domain Family A Member 2 RECOMBINANT & NATURAL PROTEINS 1mg
pro-781 Recombinant Human Pleckstrin Homology-Like Domain Family A Member 2 RECOMBINANT & NATURAL PROTEINS 10
pro-781 Recombinant Human Pleckstrin Homology-Like Domain Family A Member 2 RECOMBINANT & NATURAL PROTEINS 2
71-195 Anti_PHLDA3 antibody, monoclonal (4B6) PHLDA3 (Pleckstrin homology_like domain family A member 3) is a small PH (Pleckstrin homology) domain_only protein (127 a.a. in human) that is highly conserved i 100 ug
EIAAB31329 Bos taurus,Bovine,PH domain-containing family O member 2,PH domain-containing family Q member 1,Pleckstrin homology domain-containing family O member 2,Pleckstrin homology domain-containing family Q m
EIAAB31328 Mouse,Mus musculus,PH domain-containing family O member 2,PH domain-containing family Q member 1,Pleckstrin homology domain-containing family O member 2,Pleckstrin homology domain-containing family Q
EIAAB31272 FAPP2,FAPP-2,hFAPP2,Homo sapiens,Human,PH domain-containing family A member 8,Phosphatidylinositol-four-phosphate adapter protein 2,Phosphoinositol 4-phosphate adapter protein 2,Pleckstrin homology do
27-391 FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also 0.05 mg
26-936 CDC42EP4 is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. The protein has been shown to 0.05 mg
PLEKHM3 PLEKHM1 Gene pleckstrin homology domain containing, family M (with RUN domain) member 1
PLEKHN1 PLEKHM2 Gene pleckstrin homology domain containing, family M (with RUN domain) member 2


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur