Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :15784737
Publication Date : //

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.


Mutations of the DJ-1 (PARK7) gene are linked to familial Parkinson's disease. We used gene targeting to generate DJ-1-deficient mice that were viable, fertile, and showed no gross anatomical or neuronal abnormalities. Dopaminergic neuron numbers in the substantia nigra and fiber densities and dopamine levels in the striatum were normal. However, DJ-1-/- mice showed hypolocomotion when subjected to amphetamine challenge and increased striatal denervation and dopaminergic neuron loss induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine. DJ-1-/-embryonic cortical neurons showed increased sensitivity to oxidative, but not nonoxidative, insults. Restoration of DJ-1 expression to DJ-1-/- mice or cells via adenoviral vector delivery mitigated all phenotypes. WT mice that received adenoviral delivery of DJ-1 resisted 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine-induced striatal damage, and neurons overexpressing DJ-1 were protected from oxidative stress in vitro. Thus, DJ-1 protects against neuronal oxidative stress, and loss of DJ-1 may lead to Parkinson's disease by conferring hypersensitivity to dopaminergic insults.

Authors : Kim Raymond H , Smith Patrice D , Aleyasin Hossein , Hayley Shawn , Mount Matthew P , Pownall Scott , Wakeham Andrew , You-Ten Annick J , Kalia Suneil K , Horne Patrick , Westaway David , Lozano Andres M , Anisman Hymie , Park David S , Mak Tak W ,

Related products :

Catalog number Product name Quantity
PY-10158 Oxidative stress, DNA damage, and apoptosis: Anti-methyl CpG binding protein 2 (MeCP2),Chicken-Poly 100μg
PY-10189 Oxidative stress, DNA damage, and apoptosis: Anti-methyl-CpG binding domain protein 2 isoform 1(MBD2),Chicken-Poly 100μg
BPA 101 (10-Kit) 8-isoprostane oxidative stress ELISA Kit
BPA 1 (1-Kit) 8-isoprostane oxidative stress ELISA Kit
MG-0026-100 Oxidative Stress Multiplex PCR Kit 100
MG-0026-50 Oxidative Stress Multiplex PCR Kit 50
BPA 11 (2-Kit) 8-isoprostane oxidative stress ELISA Kit
BPA 21 (5-Kit) 8-isoprostane oxidative stress ELISA Kit
M320665 N-[[4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine Methyl Ester C22H24N2O4 CAS: 331746-65-7 5 mg
8iso21 5X 8_Isoprostane oxidative stress ELISA kit
8iso1 8_Isoprostane oxidative stress ELISA kit
8iso21 (5-Kit) 8-isoprostane oxidative stress ELISA Kit
8iso101 10X 8_isoprostane oxidative stress ELISA kit
GEN0801220 OXI_TEK (Oxidative Stress) 8_oxo_dG*N15 1
OS1H1_F24S Oxidative Stress,OS1H1:24 SignArrays
8iso11 2X 8_Isoprostane oxidative stress ELISA kit
8iso101 (10-Kit) 8-isoprostane oxidative stress ELISA Kit
8iso21 (5-Kit) 8-isoprostane oxidative stress ELISA Kit
OS1H1_F8S Oxidative Stress,OS1H1:8 SignArrays
8iso101 (10-Kit) 8-isoprostane oxidative stress ELISA Kit
OS1H1_R24S Oxidative Stress, OS1H1:24 SignArrays
OS1H1_R2S Oxidative Stress, OS1H1:2 SignArrays
GEN0801218 OXI_TEK (Oxidative Stress) 8_oxo_dG 1
OS1H1_R4S Oxidative Stress, OS1H1:4 SignArrays
OS1H1_R8S Oxidative Stress, OS1H1:8 SignArrays


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur