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Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin.
Myopodin was identified as a tumor suppressor gene that is frequently deleted in aggressive prostate cancer. Expression of myopodin protein suppresses both tumor growth and metastasis in vitro and in vivo. In the present study employing a yeast two-hybrid system, we found that zyxin, a molecule known to regulate cell motility and migration, binds with myopodin with high affinity. The binding between zyxin and myopodin seems to be direct. Screening of a series of myopodin deletion mutants and peptide competition analyses revealed that myopodin is bound by zyxin at a site located within the sequence of the 19 amino acids at the myopodin COOH terminus. Importantly, this is the same region where the tumor suppressor activity of myopodin is located. The motility and invasion suppression activity of myopodin were significantly weakened in myopodin mutants lacking this sequence. Thus, our studies suggest that zyxin may be a critical functional regulator of myopodin.
Authors : Yu Yan Ping , Luo Jian-Hua ,
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Pathways :
WP2292: Chemokine signaling pathway
WP1069: Integrin-mediated cell adhesion
WP1185: Integrin-mediated cell adhesion
WP1386: Integrin-mediated cell adhesion
WP1782: APC/C-mediated degradation of cell cycle proteins
WP185: Integrin-mediated cell adhesion
WP2263: Prostate Cancer
WP6: Integrin-mediated cell adhesion
WP74: Integrin-mediated cell adhesion
WP832: Integrin-mediated cell adhesion
WP951: Integrin-mediated cell adhesion
WP1011: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1043: Calcium Regulation in the Cardiac Cell
WP1078: G1 to S cell cycle control
WP1083: Cell cycle
WP1130: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1159: Calcium Regulation in the Cardiac Cell
WP1195: G1 to S cell cycle control
WP1200: Cell cycle
WP1345: T Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP1365: Calcium Regulation in the Cardiac Cell
WP1393: Cell cycle
Related Genes :
Bibliography :
[16885336] Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin.
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