Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :17292623
Publication Date : //

Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.


The Ski family of nuclear oncoproteins represses transforming growth factor-beta (TGF-beta) signaling through inhibition of transcriptional activity of Smad proteins. In this study, we identified a novel gene, fussel-15 (functional smad suppressing element on chromosome 15) with high homology to the recently discovered Fussel-18 protein. Both, Fussel-15 and Fussel-18, share important structural features, significant homology and similar genomic organization with the homolog Ski family members, Ski and SnoN. Unlike Ski and SnoN, which are ubiquitously expressed in human tissues, Fussel-15 expression, like Fussel-18, is much more restricted in its expression and is principally found in the nervous system of mouse and humans. Interestingly, Fussel-15 expression is even more restricted in adulthood to Purkinje cells of human cerebellum. In contrast to Fussel-18 that interacts with Smad 2, Smad3 and Smad4 and has an inhibitory activity on TGF-beta signaling, Fussel-15 interacts with Smad1, Smad2 and Smad3 molecules and suppresses mainly BMP signaling pathway but has only minor effects on TGF-beta signaling. This new protein expands the family of Ski/Sno proto-oncoproteins and represents a novel molecular regulator of BMP signaling.

Authors : Arndt Stephanie , Poser Ina , Moser Markus , Bosserhoff Anja-Katrin ,

Related products :

Catalog number Product name Quantity
EIAAB38582 Corl2,Fussel-18 homolog,Ladybird homeobox corepressor 1-like protein,LBX1 corepressor 1-like protein,Mouse,Mus musculus,SKI family transcriptional corepressor 2,Skor2,Transcriptional corepressor Corl2
18-003-43237 Mothers against decapentaplegic homolog 1 - SMAD 1; Mothers against DPP homolog 1; Mad-related protein 1; Transforming growth factor-beta signaling protein 1; BSP-1; hSMAD1; JV4-1 Polyclonal 0.1 mg Protein A
28-856 The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. CREG1 antagonizes transcriptional activation and cellular transfo 0.05 mg
18-661-15190 Baculoviral IAP repeat-containing protein 2 - Inhibitor of apoptosis protein 2; HIAP2; HIAP-2; C-IAP1; TNFR2-TRAF signaling complex protein 2; IAP homolog B Polyclonal 0.1 mg
EIAAB38581 CORL2,Functional Smad-suppressing element on chromosome 18,FUSSEL18,Fussel-18,Homo sapiens,Human,Ladybird homeobox corepressor 1-like protein,LBX1 corepressor 1-like protein,SKI family transcriptional
EIAAB38578 Corl1,Fussel-15 homolog,Ladybird homeobox corepressor 1,Lbx1 corepressor 1,Lbxcor1,Mouse,Mus musculus,SKI family transcriptional corepressor 1,Skor1,Transcriptional corepressor Corl1
EIAAB34563 G(z)GAP,Gz-GAP,Gz-selective GTPase-activating protein,Homo sapiens,Human,Regulator of G-protein signaling 20,Regulator of G-protein signaling Z1,Regulator of Gz-selective protein signaling 1,RGS20,RGS
CSB-EL026476HU Human Lateral signaling target protein 2 homolog(ZFYVE28) ELISA kit 96T
E1381338 Agouti Signaling Protein, Nonagouti Homolog (Mouse) (ASIP) ELISA Kit 1
CSB-EL026476MO Mouse Lateral signaling target protein 2 homolog(ZFYVE28) ELISA kit 96T
29-805 RGS18 is a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-p 0.1 mg
CSB-EL026476HU Human Lateral signaling target protein 2 homolog(ZFYVE28) ELISA kit SpeciesHuman 96T
CSB-EL026476MO Mouse Lateral signaling target protein 2 homolog(ZFYVE28) ELISA kit SpeciesMouse 96T
LST2_MOUSE ELISA Kit FOR Lateral signaling target protein 2 homolog; organism: Mouse; gene name: Zfyve28 96T
CSB-EL002212RA Rat agouti signaling protein, nonagouti homolog (mouse) (ASIP) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL002212PI Pig agouti signaling protein, nonagouti homolog (mouse) (ASIP) ELISA kit, Species Pig, Sample Type serum, plasma 96T
CSB-EL002212CA Cat agouti signaling protein, nonagouti homolog (mouse) (ASIP) ELISA kit, Species Cat, Sample Type serum, plasma 96T
CSB-EL002212DO Dog agouti signaling protein, nonagouti homolog (mouse) (ASIP) ELISA kit, Species Dog, Sample Type serum, plasma 96T
18-272-197083 cIAP1 - Rabbit polyclonal to cIAP1; Inhibitor of apoptosis protein 2; HIAP2; HIAP-2; C-IAP1; TNFR2-TRAF-signaling complex protein 2; IAP homolog B; RING finger protein 48 Polyclonal 0.05 mg
29-804 RGS8 is a member of the regulator of G protein signaling (RGS) family and is a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural component 0.1 mg
EIAAB12186 Activator of G-protein signaling 2,AGS2,Dynein light chain Tctex-type 1,Dynlt1,Rat,Rattus norvegicus,T-complex testis-specific protein 1 homolog,Tctel1,Tctex1,Tctex-1
18-272-197117 cIAP2 - Rabbit polyclonal to cIAP2; Inhibitor of apoptosis protein 1; HIAP1; HIAP-1; C-IAP2; TNFR2-TRAF-signaling complex protein 1; IAP homolog C; Apoptosis inhibitor 2; API2; RING finger protein 49 0.05 mg
18-003-42464 Regulator of G-protein signaling 16 - RGS16; Retinally abundant regulator of G-protein signaling; RGS-R; A28-RGS14P Polyclonal 0.1 mg Protein A
15-288-21321 Regulator of G-protein signaling 16 - RGS16; Retinally abundant regulator of G-protein signaling; RGS-R; A28-RGS14P Polyclonal 0.1 mg
15-288-21321 Regulator of G-protein signaling 16 - RGS16; Retinally abundant regulator of G-protein signaling; RGS-R; A28-RGS14P Polyclonal 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur