Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :17694067
Publication Date : //

The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers.


Transformation and cancer growth are regulated by the coordinate actions of oncogenes and tumor suppressors. Here, we show that the novel E3 ubiquitin ligase HACE1 is frequently downregulated in human tumors and maps to a region of chromosome 6q21 implicated in multiple human cancers. Genetic inactivation of HACE1 in mice results in the development of spontaneous, late-onset cancer. A second hit from either environmental triggers or genetic heterozygosity of another tumor suppressor, p53, markedly increased tumor incidence in a Hace1-deficient background. Re-expression of HACE1 in human tumor cells directly abrogates in vitro and in vivo tumor growth, whereas downregulation of HACE1 via siRNA allows non-tumorigenic human cells to form tumors in vivo. Mechanistically, the tumor-suppressor function of HACE1 is dependent on its E3 ligase activity and HACE1 controls adhesion-dependent growth and cell cycle progression during cell stress through degradation of cyclin D1. Thus, HACE1 is a candidate chromosome 6q21 tumor-suppressor gene involved in multiple cancers.

Authors : Zhang Liyong , Anglesio Michael S , O'Sullivan Maureen , Zhang Fan , Yang Ge , Sarao Renu , Mai P Nghiem , Cronin Shane , Hara Hiromitsu , Melnyk Nataliya , Li Liheng , Wada Teiji , Liu Peter P , Farrar Jason , Arceci Robert J , Sorensen Poul H , Penninger Josef M ,

Related products :

Catalog number Product name Quantity
26-860 Tusc1 gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer a 0.05 mg
32-172 p16 (cyclin-dependent kinase inhibitor 2A, INK4a) is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 _ Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malign 0.1 mL
26-056 TMEFF1 may inhibit NODAL and BMP signaling during neural patterning. It may be a tumor suppressor in brain cancers. 0.05 mg
25-845 HACE1 contains 6 ANK repeats and 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. HACE1 is an E3 ubiquitin-protein ligase that may function in cellular proteins degradation. 0.05 mg
CSB-EL010115MO Mouse E3 ubiquitin-protein ligase HACE1(HACE1) ELISA kit SpeciesMouse 96T
CSB-EL010115HU Human E3 ubiquitin-protein ligase HACE1(HACE1) ELISA kit SpeciesHuman 96T
CSB-EL010115HU Human E3 ubiquitin-protein ligase HACE1(HACE1) ELISA kit 96T
CSB-EL010115MO Mouse E3 ubiquitin-protein ligase HACE1(HACE1) ELISA kit 96T
E4918m ELISA Kit FOR E3 ubiquitin-protein ligase HACE1; organism: Mouse; gene name: Hace1 96T
EIAAB43851 B-cell chronic lymphocytic leukemia tumor suppressor Leu5,E3 ubiquitin-protein ligase TRIM13,Homo sapiens,Human,LEU5,Leukemia-associated protein 5,Putative tumor suppressor RFP2,Ret finger protein 2,R
31-024 TP53 acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activat 0.1 mg
gen11544 CD2A1_HUMAN Multiple tumor suppressor 1 ELISA tesk kit 1
18-003-42900 Cyclin-dependent kinase 4 inhibitor B - p14-INK4b; p15-INK4b; Multiple tumor suppressor 2; MTS2 Polyclonal 0.1 mg Protein A
18-003-42900 Cyclin-dependent kinase 4 inhibitor B - p14-INK4b; p15-INK4b; Multiple tumor suppressor 2; MTS2 Polyclonal 0.05 mg Aff Pur
18-003-42901 Cyclin-dependent kinase 4 inhibitor B - p14-INK4b; p15-INK4b; Multiple tumor suppressor 2; MTS2 Polyclonal 0.05 mg Aff Pur
18-003-42901 Cyclin-dependent kinase 4 inhibitor B - p14-INK4b; p15-INK4b; Multiple tumor suppressor 2; MTS2 Polyclonal 0.1 mg Protein A
EIAAB06570 CDKN2B,Cyclin-dependent kinase 4 inhibitor B,Homo sapiens,Human,MTS2,MTS-2,Multiple tumor suppressor 2,p14-INK4b,p15INK4B,p15-INK4b
EIAAB25787 Angiotensin-II type 2 receptor-interacting protein,Atip,Microtubule-associated tumor suppressor 1 homolog,Mitochondrial tumor suppressor 1 homolog,Mtsg1,Mtus1,Rat,Rattus norvegicus
31-334 RBL1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regula 0.05 mg
29-844 RNF40 contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the 0.1 mg
EIAAB25785 Bos taurus,Bovine,Microtubule-associated tumor suppressor 1 homolog,Mitochondrial tumor suppressor 1 homolog,MTUS1
EH2298 E3 ubiquitin-protein ligase HACE1 Elisa Kit 96T
MC541 Multiple organ, diseased tissue array (54 cases_54 cores, 18 types of cancers), replaced by MC542
18-783-78998 GOAT ANTI PTEN - PHOSPHATASE AND TENSIN HOMOLOGUE (MUTATED IN MULTIPLE ADVANCED CANCERS 1) Polyclonal 0.1 mg
EIAAB25786 Angiotensin-II type 2 receptor-interacting protein,AT2 receptor-binding protein,ATBP,ATIP,GK1,Homo sapiens,Human,KIAA1288,Microtubule-associated tumor suppressor 1,Mitochondrial tumor suppressor 1,MTS


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur