Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :17965020
Publication Date : //

The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha.


To identify new potential substrates for the MAP kinase signal-integrating kinases (Mnks), we employed a proteomic approach. The Mnks are targeted to the translational machinery through their interaction with the cap-binding initiation factor complex. We tested whether proteins retained on cap resin were substrates for the Mnks in vitro, and identified one such protein as PSF (the PTB (polypyrimidine tract-binding protein)-associated splicing factor). Mnks phosphorylate PSF at two sites in vitro, and our data show that PSF is an Mnk substrate in vivo. We also demonstrate that PSF, together with its partner, p54(nrb), binds RNAs that contain AU-rich elements (AREs), such as those for proinflammatory cytokines (e.g. tumor necrosis factor alpha (TNFalpha)). Indeed, PSF associates specifically with the TNFalpha mRNA in living cells. PSF is phosphorylated at two sites by the Mnks. Our data show that Mnk-mediated phosphorylation increases the binding of PSF to the TNFalpha mRNA in living cells. These findings identify a novel Mnk substrate. They also suggest that the Mnk-catalyzed phosphorylation of PSF may regulate the fate of specific mRNAs by modulating their binding to PSF.p54(nrb).

Authors : Buxadé Maria , Morrice Nick , Krebs Danielle L , Proud Christopher G ,

Related products :

Catalog number Product name Quantity
20-321-175089 TUMOR NECROSIS FACTOR-ALPHA (TNF-alpha) - MONOCLONAL ANTIBODY TO HUMAN TUMOR NECROSIS FACTOR-ALPHA (TNF-alpha); TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin Monoclona 0.1 mg
20-321-175108 TUMOR NECROSIS FACTOR ALPHA (TNF-alpha) - BIOTINYLATED MONOCLONAL ANTIBODY TO HUMAN TUMOR NECROSIS FACTOR ALPHA (TNF-alpha); TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachec 0.05 mg
20-321-175107 TUMOR NECROSIS FACTOR ALPHA (TNF-alpha) - MONOCLONAL ANTIBODY TO HUMAN TUMOR NECROSIS FACTOR ALPHA (TNF-alpha); TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin Monoclona 0.1 mg
20-321-175109 TUMOR NECROSIS FACTOR ALPHA (TNF-alpha) - MONOCLONAL ANTIBODY TO HUMAN TUMOR NECROSIS FACTOR ALPHA (TNF-alpha); TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin Monoclona 0.1 mg
20-321-175110 TUMOR NECROSIS FACTOR ALPHA (TNF-alpha) - BIOTINYLATED MONOCLONAL ANTIBODY TO HUMAN TUMOR NECROSIS FACTOR ALPHA (TNF-alpha); TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachec 0.05 mg
20-321-175090 TUMOR NECROSIS FACTOR-ALPHA (TNF-alpha) - MONOCLONAL ANTIBODY TO HUMAN TUMOR NECROSIS FACTOR-ALPHA (TNF-alpha); TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin Monoclona 0.1 mg
20-271-80049 Tumor Necrosis Factor-alpha - Mouse Anti Human Tumor Necrosis Factor-alpha; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin Monoclonal 0.5 mg
20-271-80049 Tumor Necrosis Factor-alpha - Mouse Anti Human Tumor Necrosis Factor-alpha; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin Monoclonal 1 mg
20-663-48023 Tumor Necrosis Factor-alpha (mAHuTNF-a) - Mouse Anti Human Tumor Necrosis Factor-alpha (mAHuTNF-a); TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin Monoclonal 1 mg
20-663-48023 Tumor Necrosis Factor-alpha (mAHuTNF-a) - Mouse Anti Human Tumor Necrosis Factor-alpha (mAHuTNF-a); TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin Monoclonal 0.5 mg
25-616 KHSRP binds to the dendritic targeting element and may play a role in mRNA trafficking. It is part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. KHSRP media 0.05 mg
18-321-177015 TUMOR NECROSIS FACTOR-alpha - POLYCLONAL ANTIBODY TO HUMAN TUMOR NECROSIS FACTOR-alpha; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin Polyclonal 0.1 mg
10-321-179006 TUMOR NECROSIS FACTOR ALPHA (E.Coli-DERIVED) - RECOMBINANT MOUSE TUMOR NECROSIS FACTOR ALPHA (E.Coli-DERIVED) (5x104 units); TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachec 520 Units
10-321-179009 TUMOR NECROSIS FACTOR ALPHA (E.Coli-DERIVED) - RECOMBINANT HUMAN TUMOR NECROSIS FACTOR ALPHA (E.Coli-DERIVED) (5x104 units); TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachec 520 Units
U0132r CLIA p75,p80 TNF-alpha receptor,Rat,Rattus norvegicus,Tnfr2,TNF-R2,TNF-RII,TNFR-II,Tnfrsf1b,Tumor necrosis factor receptor 2,Tumor necrosis factor receptor superfamily member 1B,Tumor necrosis factor 96T
E0132r ELISA p75,p80 TNF-alpha receptor,Rat,Rattus norvegicus,Tnfr2,TNF-R2,TNF-RII,TNFR-II,Tnfrsf1b,Tumor necrosis factor receptor 2,Tumor necrosis factor receptor superfamily member 1B,Tumor necrosis factor 96T
U0132h CLIA Homo sapiens,Human,p75,p80 TNF-alpha receptor,TNFBR,TNFR2,TNF-R2,TNF-RII,TNFR-II,TNFRSF1B,Tumor necrosis factor receptor 2,Tumor necrosis factor receptor superfamily member 1B,Tumor necrosis fact 96T
E0132h ELISA Homo sapiens,Human,p75,p80 TNF-alpha receptor,TNFBR,TNFR2,TNF-R2,TNF-RII,TNFR-II,TNFRSF1B,Tumor necrosis factor receptor 2,Tumor necrosis factor receptor superfamily member 1B,Tumor necrosis fac 96T
10-663-45249 Tumor Necrosis Factor Receptor Fusion Protein (TNFR) Human - Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; CD120b antigen; Etanercept N 0.05 mg
10-663-45249 Tumor Necrosis Factor Receptor Fusion Protein (TNFR) Human - Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; CD120b antigen; Etanercept N 0.01 mg
10-663-45249 Tumor Necrosis Factor Receptor Fusion Protein (TNFR) Human - Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; CD120b antigen; Etanercept N 1 mg
10-663-45232 Tumor Necrosis Factor-alpha (TNF-alpha) Porcine - TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin N_A 0.02 mg
10-663-45232 Tumor Necrosis Factor-alpha (TNF-alpha) Porcine - TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin N_A 1 mg
10-663-45232 Tumor Necrosis Factor-alpha (TNF-alpha) Porcine - TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin N_A 0.005 mg
10-663-45092 Tumor Necrosis Factor-alpha (TNF-alpha) Human - TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Cachectin N_A 1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur