GENTAUR antibody-antibodies.com The Marketplace for Antibodies : TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :18568018
Publication Date : //

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.

Transforming growth factor-beta (TGFbeta) family members regulate many developmental and pathological events through Smad transcriptional modulators. How nuclear accumulation of Smad is coupled to the transcriptional machinery is poorly understood. Here we demonstrate that in response to TGFbeta stimulation the transcriptional regulator TAZ binds heteromeric Smad2/3-4 complexes and is recruited to TGFbeta response elements. In human embryonic stem cells TAZ is required to maintain self-renewal markers and loss of TAZ leads to inhibition of TGFbeta signalling and differentiation into a neuroectoderm lineage. In the absence of TAZ, Smad2/3-4 complexes fail to accumulate in the nucleus and activate transcription. Furthermore, TAZ, which itself engages in shuttling, dominantly controls Smad nucleocytoplasmic localization and can be retained in the nucleus by transcriptional co-factors such as ARC105, a component of the Mediator complex. TAZ thus defines a hierarchical system regulating Smad nuclear accumulation and coupling to the transcriptional machinery.

Authors : Varelas Xaralabos , Sakuma Rui , Samavarchi-Tehrani Payman , Peerani Raheem , Rao Balaji M , Dembowy Joanna , Yaffe Michael B , Zandstra Peter W , Wrana Jeffrey L ,

Related products :

Catalog number	Product name	Quantity

29-029	ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons.	0.05 mg
L043V2	Catalogue Whole Cell Lysate (Human embryonic stem cell)	50 µg
L043V2	hES-TW1(human embryonic stem cell) whole cell lysate (non-denatured)	50 ug
F0660-050	FBS,Human Embryonic Stem cell and iPSC Optimized	500ml
HUXES-90011	Human Embryonic Stem Cell Culture Medium	500 mL
HESRG_HUMAN	Human ELISA Kit FOR Embryonic stem cell-related gene protein	96T
L044V2	ES-D3 (mouse pluripotent embryonic stem cell) whole cell lysate (non-denatured)	50 ug
L045V2	ES-E14TG2a (mouse pluripotent embryonic stem cell) whole cell lysate (non-denatured)	50 ug
MUXES-90011	Mouse Embryonic Stem Cell Culture Medium Cell Culture Media Cell Screening, Differentiation_Stem Cells	500 mL
4751	an embryonic stem cell protein	0.1 mg
4755	an embryonic stem cell protein	0.1 mg
4755	an embryonic stem cell protein	0.5 mg
GEN52TXWES	Embryonic Stem Cell Medium	250 ml.
4751	an embryonic stem cell protein	0.5 mg
CBA-304	Total RNA _ Murine Embryonic Stem Cell Line D3	50
CBA-304	Total RNA - Murine Embryonic Stem Cell Line D3	50 μg
CBA-304	Total RNA _ Murine Embryonic Stem Cell Line D3	50 ìg
CBA-304	Total RNA - Murine Embryonic Stem Cell Line D3	50 μg
CBA-305	Total Protein _ Murine Embryonic Stem Cell Line D3	500
CBA-305	Total Protein - Murine Embryonic Stem Cell Line D3	500 μg
CBA-305	Total Protein - Murine Embryonic Stem Cell Line D3	500 μg
F0650-050	FBS,Mouse Embryonic Stem cell and iPSC Optimized	500ml
GEM-100-125-H	Foetal Bovine Serum _ Embryonic Stem Cell USDA	100ml
GEM-100-125-F	Foetal Bovine Serum _ Embryonic Stem Cell USDA	500ml
CBA-305	Total Protein _ Murine Embryonic Stem Cell Line D3	500 ìg

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur

GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel: 0208-080893 Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62 SWIFT RABONL2U

GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur

ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF