GENTAUR Molecular Products.
Monoclonal Antibody, ELISA Kit, Polyclonal Antibody, Recombinant/Purified Protein.Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery
Publication Date : //
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
Transforming growth factor-beta (TGFbeta) family members regulate many developmental and pathological events through Smad transcriptional modulators. How nuclear accumulation of Smad is coupled to the transcriptional machinery is poorly understood. Here we demonstrate that in response to TGFbeta stimulation the transcriptional regulator TAZ binds heteromeric Smad2/3-4 complexes and is recruited to TGFbeta response elements. In human embryonic stem cells TAZ is required to maintain self-renewal markers and loss of TAZ leads to inhibition of TGFbeta signalling and differentiation into a neuroectoderm lineage. In the absence of TAZ, Smad2/3-4 complexes fail to accumulate in the nucleus and activate transcription. Furthermore, TAZ, which itself engages in shuttling, dominantly controls Smad nucleocytoplasmic localization and can be retained in the nucleus by transcriptional co-factors such as ARC105, a component of the Mediator complex. TAZ thus defines a hierarchical system regulating Smad nuclear accumulation and coupling to the transcriptional machinery.
Authors : Varelas Xaralabos , Sakuma Rui , Samavarchi-Tehrani Payman , Peerani Raheem , Rao Balaji M , Dembowy Joanna , Yaffe Michael B , Zandstra Peter W , Wrana Jeffrey L ,
Related products :
GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45
Fax 0032 16 50 90 45
info@gentaur.com | Gentaur
GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur
GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50
Fax 01 43 25 01 60
RCS Paris B 484 237 888
SIRET 48423788800017
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
france@gentaur.com | Gentaur
GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur
GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel: 0208-080893 Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62 SWIFT RABONL2U
GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur
ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF
GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX 058 710 33 48
poland@gentaur.com | Gentaur
Other countries
Österreich +43720880899
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Danmark +4569918806
Finland Helsset +358942419041
Magyarország Budapest +3619980547
Ireland Dublin+35316526556
Luxembourg+35220880274
Norge Oslo+4721031366
Sverige Stockholm+46852503438
Schweiz Züri+41435006251
US New York+17185132983
GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo
Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur
Pathways :
WP1411: Cell Division: First embryonic mitosis
WP1011: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1043: Calcium Regulation in the Cardiac Cell
WP1069: Integrin-mediated cell adhesion
WP1078: G1 to S cell cycle control
WP1083: Cell cycle
WP1130: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1159: Calcium Regulation in the Cardiac Cell
WP1185: Integrin-mediated cell adhesion
WP1195: G1 to S cell cycle control
WP1200: Cell cycle
WP1345: T Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP1365: Calcium Regulation in the Cardiac Cell
WP1386: Integrin-mediated cell adhesion
WP1393: Cell cycle
WP1596: Iron Homeostasis
WP1775: Cell Cycle Checkpoints
WP1782: APC/C-mediated degradation of cell cycle proteins
WP179: Cell cycle
WP1792: Cell Cycle, Mitotic
WP1793: Cell junction organization
WP1794: Cell surface interactions at the vascular wall
Related Genes :
[BT3 At1g05690 F3F20.14] BTB/POZ and TAZ domain-containing protein 3 (BTB and TAZ domain protein 3)
[BT5 At4g37610 F19F18.100] BTB/POZ and TAZ domain-containing protein 5 (BTB and TAZ domain protein 5)
[BT1 At5g63160 MDC12.13] BTB/POZ and TAZ domain-containing protein 1 (BTB and TAZ domain protein 1)
[BT2 At3g48360 T29H11.120] BTB/POZ and TAZ domain-containing protein 2 (BTB and TAZ domain protein 2)
[BT4 At5g67480 K9I9.4] BTB/POZ and TAZ domain-containing protein 4 (BTB and TAZ domain protein 4)
[taz1 myb myb1 SPAC16A10.07c] Telomere length regulator taz1
[TAZ EFE2 G4.5] Tafazzin (Protein G4.5)
[WWTR1 TAZ] WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
[TAZ1 YPR140W] Lysophosphatidylcholine acyltransferase (EC 2.3.1.23) (1-acylglycerophosphocholine O-acyltransferase) (Tafazzin homolog) (lyso-PC acyltransferase)
[taf1 atg11 cvt9 SPAC7D4.04] Taz1-interacting factor 1 (Protein taf1) (Autophagy-related protein 11) (Cytoplasm to vacuole targeting protein 9)
[Wwtr1 Taz] WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
[Taz CG8766] Tafazzin homolog (dTAZ)
[ZBTB18 RP58 TAZ1 ZNF238] Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger protein 238) (Zinc finger protein C2H2-171)
[ndhF] NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic (EC 1.6.5.-) (NADH-plastoquinone oxidoreductase subunit 5) (Fragment)
[Taz Taz_mapped rCG_43825] Tafazzin (Tafazzin (Cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) (Mapped), isoform CRA_c)
[Dis3 dDis3 dis3 Dmel\CG6413 dRrp44 Rrp44 Taz taz CG6413 Dmel_CG6413] Dis3, isoform A (Dis3, isoform B)
[Taz RP23-436K3.6-015] Tafazzin
[cob] Cytochrome b (Fragment)
[taz DDB_G0291922] Putative lysophosphatidylcholine acyltransferase (EC 2.3.1.23) (1-acylglycerophosphocholine O-acyltransferase) (Tafazzin homolog)
[Taz] Tafazzin (Tafazzin exon 5 and exon 9 deleted variant long form)
[Taz] Tafazzin
[Taz] Tafazzin (Fragment)
[CREBBP CBP] CREB-binding protein (EC 2.3.1.48)
[Crebbp Cbp] CREB-binding protein (EC 2.3.1.48)
[EP300 P300] Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
[Taz mCG_129905 RP23-436K3.6-001] Tafazzin (Tafazzin exon 5 deleted variant long form) (Tafazzin, isoform CRA_e)
[Taz RP23-436K3.6-020] Tafazzin
[Crebbp Cbp] CREB-binding protein (EC 2.3.1.48)
[Ep300 P300] Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
[Taz] Uncharacterized protein
Bibliography :
No related Items
Share this page:
Enter catalog number :
Favorites Pages:
No Favorits