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Pubmed ID :18647839
Publication Date : //

D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein.


Despite extensive data demonstrating that immature retroviral particle assembly can take place either at the plasma membrane or at a distinct location within the cytoplasm, targeting of viral precursor proteins to either assembly site still remains poorly understood. Biochemical data presented here suggest that Tctex-1, a light chain of the molecular motor dynein, is involved in the intracellular targeting of Mason-Pfizer monkey virus (M-PMV) polyproteins to the cytoplasmic assembly site. Comparison of the three-dimensional structures of M-PMV wild-type matrix protein (wt MA) with a single amino acid mutant (R55F), which redirects assembly from a cytoplasmic site to the plasma membrane, revealed different mutual orientations of their C- and N-terminal domains. This conformational change buries a putative intracellular targeting motif located between both domains in the hydrophobic pocket of the MA molecule, thereby preventing the interaction with cellular transport mechanisms.

Authors : Vlach Jirí , Lipov Jan , Rumlová Michaela , Veverka Václav , Lang Jan , Srb Pavel , Knejzlík Zdenek , Pichová Iva , Hunter Eric , Hrabal Richard , Ruml Tomás ,

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