Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :18760366
Publication Date : //

Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes.


The cell adhesion molecule TAG-1 is expressed by neurons and glial cells and plays a role in axon outgrowth, migration and fasciculation during development. TAG-1 is also required for the clustering of Kv1.1/1.2 potassium channels and Caspr2 at the juxtaparanodes of myelinated fibers. Behavioral examination of TAG-1 deficient mice (Tag-1(-/-)) showed cognitive impairments in the Morris water maze and novel object recognition tests, reduced spontaneous motor activity, abnormal gait coordination and increased response latency to noxious stimulation. Investigation at the molecular level revealed impaired juxtaparanodal clustering of Caspr2 and Kv1.1/1.2 in the hippocampus, entorhinal cortex, cerebellum and olfactory bulb, with diffusion into the internode. Caspr2 and Kv1.1 levels were reduced in the cerebellum and olfactory bulb. Moreover, Tag-1(-/-) mice had shorter internodes in the cerebral and cerebellar white matter. The detected molecular alterations may account for the behavioural deficits and hyperexcitability in these animals.

Authors : Savvaki Maria , Panagiotaropoulos Theofanis , Stamatakis Antonis , Sargiannidou Irene , Karatzioula Pinelopi , Watanabe Kazutada , Stylianopoulou Fotini , Karagogeos Domna , Kleopa Kleopas A ,

Related products :

Catalog number Product name Quantity
30-158 Hearing impairment is a heterogeneous condition with over 40 loci described. DFNA5 is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with 0.1 mg
ASCITE-1 Custom Production of Ascites in Balb c mice (min 20 mice @$30 mice plus; $300 per cell line for cell culture) 1
ASCITE-1 Custom Production of Ascites in Balb_c mice (min 20 mice @$30_mice plus; $300 per cell line for cell culture) Species Reactivity: 1 Product tipe: Service
ASCITE-1 Custom Production of Ascites in Balb_c mice (min 20 mice @$30_mice plus; $300 per cell line for cell culture) 1
EIAAB11283 DIRC1,Disrupted in renal cancer protein,Disrupted in renal carcinoma protein 1,Homo sapiens,Human
EIAAB11286 DIRC2,Disrupted in renal cancer protein 2,Disrupted in renal carcinoma protein 2,Homo sapiens,Human
KMC0163 I. V. Training arm for adult appropriate for learning injection Set
ASC-AST-2002 TARGATT™ Rosa26 Mouse Genotyping Kit for genotyping of TARGATT™ mice and knock-in mice generated from TARGATT™embryos via tail lysis 100 reactions
ASC-AST-2002 TARGATT™ Rosa26 Mouse Genotyping Kit for genotyping of TARGATT™ mice and knock-in mice generated from TARGATT™embryos via tail lysis 100 reactions
KMC0162 I. V. Training arm for adult appropriate for injection and phlebotomy learning Set
ASC-AST-2001 TARGATT™ H11 Mouse Genotyping Kit for genotyping of TARGATT™ mice and knock-in mice generated from TARGATT™ embryos via tail lysis 100 reactions
ASC-AST-2001 TARGATT™ H11 Mouse Genotyping Kit for genotyping of TARGATT™ mice and knock-in mice generated from TARGATT™ embryos via tail lysis 100 reactions
KMC0163 I. V. Training arm for adult appropriate for learning injection, Natural size
KMC0162 I. V. Training arm for adult appropriate for injection and phlebotomy learning, Natural size
076810 Globalmark 64 MB memory card 1
036607 GraphicsPro Memory Pack 1
1598 CD4+CD45RO+ (MEMORY CD4 LYMPHOCYTES), BLOOD 1
abx110052 Polyclonal Rabbit Non-syndromic hearing impairment protein 5 Antibody 100 μg
CSB-EL006766HU Human Non-syndromic hearing impairment protein 5(DFNA5) ELISA kit 96T
abx108563 Polyclonal Rabbit Non-syndromic hearing impairment protein 5 Antibody (HRP) 100 μg
CSL-MDOC-WIFI Optional 4GB wireless memory card
abx105724 Polyclonal Rabbit Non-syndromic hearing impairment protein 5 Antibody (Biotin) 100 μg
abx107142 Polyclonal Rabbit Non-syndromic hearing impairment protein 5 Antibody (FITC) 100 μg
CSB-EL006766HU Human Non-syndromic hearing impairment protein 5(DFNA5) ELISA kit SpeciesHuman 96T
AK9563-0000 CD4+_CD45RO+ Memory T Cells (Positively Selected) Inquire


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur