Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :19546860
Publication Date : //

The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.


Previous studies have implicated DTNBP1 as a schizophrenia susceptibility gene and its encoded protein, dysbindin, as a potential regulator of synaptic vesicle physiology. In this study, we found that endogenous levels of the dysbindin protein in the mouse brain are developmentally regulated, with higher levels observed during embryonic and early postnatal ages than in young adulthood. We obtained biochemical evidence indicating that the bulk of dysbindin from brain exists as a stable component of biogenesis of lysosome-related organelles complex-1 (BLOC-1), a multi-subunit protein complex involved in intracellular membrane trafficking and organelle biogenesis. Selective biochemical interaction between brain BLOC-1 and a few members of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) superfamily of proteins that control membrane fusion, including SNAP-25 and syntaxin 13, was demonstrated. Furthermore, primary hippocampal neurons deficient in BLOC-1 displayed neurite outgrowth defects. Taken together, these observations suggest a novel role for the dysbindin-containing complex, BLOC-1, in neurodevelopment, and provide a framework for considering potential effects of allelic variants in DTNBP1--or in other genes encoding BLOC-1 subunits--in the context of the developmental model of schizophrenia pathogenesis.

Authors : Ghiani C A , Starcevic M , Rodriguez-Fernandez I A , Nazarian R , Cheli V T , Chan L N , Malvar J S , de Vellis J , Sabatti C , Dell'Angelica E C ,

Related products :

Catalog number Product name Quantity
31-133 Snap25 contains 2 t-SNARE coiled-coil homology domains and belongs to the SNAP-25 family. t-SNARE involved in the molecular regulation of neurotransmitter release. Snap25 may play an important role in 0.05 mg
E0631h ELISA kit Amphiregulin-associated protein,ARAP,Homo sapiens,Human,MDK,Midgestation and kidney protein,Midkine,MK,MK1,NEGF2,Neurite outgrowth-promoting factor 2,Neurite outgrowth-promoting protein 96T
E0631h ELISA Amphiregulin-associated protein,ARAP,Homo sapiens,Human,MDK,Midgestation and kidney protein,Midkine,MK,MK1,NEGF2,Neurite outgrowth-promoting factor 2,Neurite outgrowth-promoting protein 96T
U0631h CLIA Amphiregulin-associated protein,ARAP,Homo sapiens,Human,MDK,Midgestation and kidney protein,Midkine,MK,MK1,NEGF2,Neurite outgrowth-promoting factor 2,Neurite outgrowth-promoting protein 96T
10-663-45268 Midkine (MK) Human - MK; Neurite outgrowth-promoting protein; Midgestation and kidney protein; Amphiregulin-associated protein; ARAP; Neurite outgrowth-promoting factor 2 N_A 0.005 mg
10-663-45268 Midkine (MK) Human - MK; Neurite outgrowth-promoting protein; Midgestation and kidney protein; Amphiregulin-associated protein; ARAP; Neurite outgrowth-promoting factor 2 N_A 1 mg
10-663-45268 Midkine (MK) Human - MK; Neurite outgrowth-promoting protein; Midgestation and kidney protein; Amphiregulin-associated protein; ARAP; Neurite outgrowth-promoting factor 2 N_A 0.02 mg
EIAAB26511 Ncdn,Neurite outgrowth-related protein from the rat brain,Neurochondrin,Norbin,Rat,Rattus norvegicus
26-937 CHORDC1 may be play a role in the regulation of NOD1 via its interaction with HSP90AA1. 0.05 mg
29-543 WNT proteins are secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryog 0.1 mg
25-684 WNT proteins are secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryog 0.05 mg
27-349 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation_deacetylation alters chromosome structure and affects transcription f 0.05 mg
28-136 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation_deacetylation alters chromosome structure and affects transcription f 0.05 mg
29-802 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation_deacetylation alters chromosome structure and affects transcription f 0.1 mg
29-538 WNT9B is a member of the WNT family. They are secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate 0.1 mg
26-158 The WNT family consists of several secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and pattern 0.05 mg
29-320 WNT9B is a member of the WNT family. They are secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate 0.05 mg
27-871 The WNT family consists of sereval secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and pattern 0.1 mg
30-191 Proteins that contain formin homology (FH) domains, such as FHOD3, play a role in regulation of the actin cytoskeleton. 0.05 mg
4087 (NT) a myelin-associated neurite outgrowth inhibitor 0.5 mg
4089 (IN) a myelin-associated neurite outgrowth inhibitor 0.5 mg
4101 a neurite-outgrowth promoting protein 0.5 mg
4101 a neurite-outgrowth promoting protein 0.1 mg
4089 (IN) a myelin-associated neurite outgrowth inhibitor 0.1 mg
Nogo-P4 Rat Neurite outgrowth inhibitory peptide 1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur