Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :20080667
Publication Date : //

Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.


A single nucleotide polymorphism in the DAB2IP gene is associated with risk of aggressive prostate cancer (PCa), and loss of DAB2IP expression is frequently detected in metastatic PCa. However, the functional role of DAB2IP in PCa remains unknown. Here, we show that the loss of DAB2IP expression initiates epithelial-to-mesenchymal transition (EMT), which is visualized by repression of E-cadherin and up-regulation of vimentin in both human normal prostate epithelial and prostate carcinoma cells as well as in clinical prostate-cancer specimens. Conversely, restoring DAB2IP in metastatic PCa cells reversed EMT. In DAB2IP knockout mice, prostate epithelial cells exhibited elevated mesenchymal markers, which is characteristic of EMT. Using a human prostate xenograft-mouse model, we observed that knocking down endogenous DAB2IP in human carcinoma cells led to the development of multiple lymph node and distant organ metastases. Moreover, we showed that DAB2IP functions as a scaffold protein in regulating EMT by modulating nuclear beta-catenin/T-cell factor activity. These results show the mechanism of DAB2IP in EMT and suggest that assessment of DAB2IP may provide a prognostic biomarker and potential therapeutic target for PCa metastasis.

Authors : Xie Daxing , Gore Crystal , Liu Jun , Pong Rey-Chen , Mason Ralph , Hao Guiyang , Long Michael , Kabbani Wareef , Yu Luyang , Zhang Haifeng , Chen Hong , Sun Xiankai , Boothman David A , Min Wang , Hsieh Jer-Tsong ,

Related products :

Catalog number Product name Quantity
EMT1H1_F12S Epithelial to Mesenchymal Transition (EMT),EMT1H1:12 SignArrays
EMT1H1_B4S Epithelial to Mesenchymal Transition (EMT),EMT1H1,4 SignArrays
EMT1H1_B8S Epithelial to Mesenchymal Transition (EMT),EMT1H1,8 SignArrays
EMT1H2_R2S Epithelial to Mesenchymal Transition (EMT) ,EMT1H2:2 SignArrays
EMT1H2_R4S Epithelial to Mesenchymal Transition (EMT) ,EMT1H2:4 SignArrays
EMT1H1_F24S Epithelial to Mesenchymal Transition (EMT),EMT1H1:24 SignArrays
EMT1H1_R8S Epithelial to Mesenchymal Transition (EMT) ,EMT1H1:8 SignArrays
EMT1H1_R4S Epithelial to Mesenchymal Transition (EMT) ,EMT1H1:4 SignArrays
EMT1H1_F2S Epithelial to Mesenchymal Transition (EMT),EMT1H1:2 SignArrays
EMT1H1_R2S Epithelial to Mesenchymal Transition (EMT) ,EMT1H1:2 SignArrays
EMT1H1_R24S Epithelial to Mesenchymal Transition (EMT) ,EMT1H1:24 SignArrays
EMT1H1_F4S Epithelial to Mesenchymal Transition (EMT),EMT1H1:4 SignArrays
EMT1H1_R12S Epithelial to Mesenchymal Transition (EMT) ,EMT1H1:12 SignArrays
EMT1H1_B2S Epithelial to Mesenchymal Transition (EMT),EMT1H1,2 SignArrays
EMT1H1_F8S Epithelial to Mesenchymal Transition (EMT),EMT1H1:8 SignArrays
EMT1H1_B12S Epithelial to Mesenchymal Transition (EMT),EMT1H1,12 SignArrays
EMT1H1_B24S Epithelial to Mesenchymal Transition (EMT),EMT1H1,24 SignArrays
EIAAB40264 Homo sapiens,Human,Metalloreductase STEAP2,PCANAP1,Prostate cancer-associated protein 1,Protein upregulated in metastatic prostate cancer,PUMPCn,Six-transmembrane epithelial antigen of prostate 2,SixT
4-20251 Epithelial Dissociation System 1 (Intestinal mesenchymal and epithelial,Liver epithelial,Mammary epithelial), Mouse and Rat ea
29-034 ERGIon Channel2 possibly play role in transport between endoplasmic reticulum and Golgi. ERGIon Channel2 is downregulated in prostate cancer. ERGIon Channel2 may play an important role in the growth a 0.1 mg
EnDMT1H1_F24S Endothelial to Mesenchymal Transition (EndMT),EndMT1H1:24 SignArrays
EnDMT1H1_F4S Endothelial to Mesenchymal Transition (EndMT),EndMT1H1:4 SignArrays
EnDMT1H1_F12S Endothelial to Mesenchymal Transition (EndMT),EndMT1H1:12 SignArrays
EnDMT1H1_F2S Endothelial to Mesenchymal Transition (EndMT),EndMT1H1:2 SignArrays
EnDMT1H1_F8S Endothelial to Mesenchymal Transition (EndMT),EndMT1H1:8 SignArrays


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur