Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :20447407
Publication Date : //

Asymmetric recruitment of cIAPs by TRAF2.


Cellular inhibitor of apoptosis protein (cIAP) 1 and cIAP2 set the balance between transcription factor and apoptosis signaling downstream of tumor necrosis factor (TNF) receptor superfamily members by acting as ubiquitin E3 ligases for substrates that are part of the TNF receptor complex. To fulfill this role, cIAPs must be recruited to the receptor complex by TNF-receptor-associated factor (TRAF) 2. In this study, we reconstituted the complex between baculoviral IAP repeat (BIR) 1 of cIAP1 and the coiled-coil region of TRAF2, solved the structure of BIR1 from cIAP1, and mapped key binding residues on each molecule using mutagenesis. Biophysical analysis indicates that a single BIR1 domain binds the trimeric TRAF2 coiled-coil domain. This suggests that only one IAP molecule binds to each TRAF trimer and makes it likely that the dimeric cIAPs crosslink two TRAF trimers.

Authors : Mace Peter D , Smits Callum , Vaux David L , Silke John , Day Catherine L ,

Related products :

Catalog number Product name Quantity
A0737 TRAF2 Polyclonal Antibody, Reactivity: H M R, Gene ID: 7186, Synonyms: TRAF2 100ug
A0962 TRAF2 Polyclonal Antibody, Reactivity: H M R, Gene ID: 7186, Synonyms: TRAF2 100ug
A0737 TRAF2 Polyclonal Antibody, Reactivity: H M R, Gene ID: 7186, Synonyms: TRAF2 200ug
A0962 TRAF2 Polyclonal Antibody, Reactivity: H M R, Gene ID: 7186, Synonyms: TRAF2 200ug
EIAAB43764 E3 ubiquitin-protein ligase TRAF2,Mouse,Mus musculus,TNF receptor-associated factor 2,Traf2
P-5004-TRAF2-96 QuantiSir Specific Gene Knockdown Quantification Kit For Cell Death_Apoptosis _ TRAF2 96 assays 96 assays
P-5004-TRAF2-96 QuantiSir Specific Gene Knockdown Quantification Kit For Cell Death_Apoptosis - TRAF2 (96 assays)
  P-5004-TRAF2-96  QuantiSir Specific Gene Knockdown Quantification Kit For Cell Death_Apoptosis _ TRAF2 (96 assays)
A0962 TRAF2 Primary Antibody, TRAF2, Species: Human Recombinant Protein Source: Rabbit Polyclonal 50ug
TRAF2 TRAF2 Gene TNF receptor-associated factor 2
20-272-190725 TRAF2 - Mouse monoclonal [33A1293] to TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3 Monoclonal 0.05 mg
LF-MA41372 anti-TRAF2 (33A1293) , Mouse monoclonal to TRAF2, Isotype IgG, Host Mouse 50 ug
20-272-191255 NALP1 - Mouse monoclonal [Nalpy1 - 4] to NALP1; Death effector filament-forming ced-4-like apoptosis protein; Nucleotide-binding domain and caspase recruitment domain; Caspase recruitment domain prote 0.05 mg
LF-PA41203 anti-TRAF2, Rabbit polyclonal to TRAF2, Isotype IgG, Host Rabbit 50
LF-PA42965 Anti-TRAF2, Goat Polyclonal to TRAF2, Isotype , Host Goat 50
EIAAB05320 CARD17,Caspase recruitment domain-containing protein 17,Caspase-1 inhibitor INCA,Homo sapiens,Human,INCA,Inhibitory caspase recruitment domain protein
EIAAB43765 E3 ubiquitin-protein ligase TRAF2,Homo sapiens,Human,TNF receptor-associated factor 2,TRAF2,TRAP3,Tumor necrosis factor type 2 receptor-associated protein 3
SCH-AHP2145 GOAT ANTI HUMAN TRAF2 (C_TERMINAL), Product Type Polyclonal Antibody, Specificity TRAF2, Target Species Human, Host Goat, Format Purified, Isotypes Polyclonal IgG, Applications E, WB, Clone 0.1 mg
AHP2145 GOAT ANTI HUMAN TRAF2 (C_TERMINAL), Product Type Polyclonal Antibody, Specificity TRAF2, Target Species Human, Host Goat, Format Purified, Isotypes Polyclonal IgG, Applications E, WB, Clone 0.1 mg
LF-PA41191 anti-Traf2 And NCK-Interacting Kinase (TNIK) , Rabbit polyclonal to Traf2 And NCK-Interacting Kinase (TNIK) , Isotype IgG, Host Rabbit 50 ug
LF-PA41190 anti-Traf2 And NCK-Interacting Kinase (TNIK) , Rabbit polyclonal to Traf2 And NCK-Interacting Kinase (TNIK) , Isotype IgG, Host Rabbit 50 ug
E02A0035 Rat Asymmetric dimethylaoyoinine elisa kit 96 Tests/kit
P0810 Anti_dimethyl ( asymmetric ) Arginine 100 ug
E02A0035 Rat Asymmetric Dimethylaoyoinine ELISA 96T/kit
E05A0035 Guinea Pig Asymmetric Dimethylaoyoinine ELISA 96T/kit


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur