Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :20478268
Publication Date : 2010/06/14

Human p38 delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14.


The mitogen-activated protein kinase (MAPK) family comprises ERK, JNK, p38 and ERK5 (big-MAPK, BMK1). UV irradiation of squamous cell carcinoma cells induced up-regulation of gene expression of chemokine BRAK/CXCL14, stimulated p38 phosphorylation, and down-regulated the phosphorylation of ERK. Human p38 MAPKs exist in 4 isoforms: p38 alpha, beta, gamma and delta. The UV stimulation of p38 phosphorylation was not inhibited by the presence of SB203580 or PD169316, inhibitors of p38 alpha and beta, suggesting p38 phosphorylation was not dependent on these 2 isoforms and that p38 gamma and/or delta was responsible for the phosphorylation. In fact, inhibition of each of these 4 p38 isoforms by the introduction of short hairpin (sh) RNAs for respective isoforms revealed that only shRNA for p38 delta attenuated the UV-induced up-regulation of BRAK/CXCL14 gene expression. In addition, over-expression of p38 isoforms in the cells showed the association of p38 delta with ERK1 and 2, concomitant with down-regulation of ERK phosphorylation. The usage of p38 delta isoform by UV irradiation is not merely due to the abundance of this p38 isoform in the cells. Because serum deprivation of the cells also induced an increase in BRAK/CXCL14 gene expression, and in this case p38 alpha and/or beta isoform is responsible for up-regulation of BRAK/CXCL14 gene expression. Taken together, the data indicate that the respective stress-dependent action of p38 isoforms is responsible for the up-regulation of the gene expression of the chemokine BRAK/CXCL14.

Authors : Ozawa Shigeyuki , Ito Shin , Kato Yasumasa , Kubota Eiro , Hata Ryu-Ichiro ,

Related products :

Catalog number Product name Quantity
100-139 BRAK (CXCL14), Host: E. coli, Species: Human, Synonyms: CXCL14; KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14 20 ug
100-139 BRAK (CXCL14) Human Host: E. coli CXCL14; KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14 20
E1607m ELISA kit B-cell and monocyte-activating chemokine,Bmac,Chemokine BRAK,C-X-C motif chemokine 14,Cxcl14,Kec,Kidney-expressed chemokine CXC,Ks1,Mip2g,MIP-2G,Mouse,Mus musculus,Scyb14,Small-inducible cy 96T
U1607m CLIA B-cell and monocyte-activating chemokine,Bmac,Chemokine BRAK,C-X-C motif chemokine 14,Cxcl14,Kec,Kidney-expressed chemokine CXC,Ks1,Mip2g,MIP-2G,Mouse,Mus musculus,Scyb14,Small-inducible cytokine 96T
E1607m ELISA B-cell and monocyte-activating chemokine,Bmac,Chemokine BRAK,C-X-C motif chemokine 14,Cxcl14,Kec,Kidney-expressed chemokine CXC,Ks1,Mip2g,MIP-2G,Mouse,Mus musculus,Scyb14,Small-inducible cytokin 96T
E1607h ELISA kit Chemokine BRAK,C-X-C motif chemokine 14,CXCL14,Homo sapiens,Human,MIP2G,MIP-2G,NJAC,PSEC0212,SCYB14,Small-inducible cytokine B14,UNQ240_PRO273 96T
E1607h ELISA Chemokine BRAK,C-X-C motif chemokine 14,CXCL14,Homo sapiens,Human,MIP2G,MIP-2G,NJAC,PSEC0212,SCYB14,Small-inducible cytokine B14,UNQ240_PRO273 96T
U1607h CLIA Chemokine BRAK,C-X-C motif chemokine 14,CXCL14,Homo sapiens,Human,MIP2G,MIP-2G,NJAC,PSEC0212,SCYB14,Small-inducible cytokine B14,UNQ240_PRO273 96T
18-003-42911 Small inducible cytokine B14 - CXCL14; Chemokine BRAK Polyclonal 0.1 mg Protein A
101-M352 CXCL14 Anti-Human Host: Mouse CXCL14; KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14 100
102-P223 BRAK Anti-Human Host: Rabbit CXCL14; KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14 100
101-M352 CXCL14, Host: Mouse, Species: Anti-Human, Synonyms: CXCL14; KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14 100 ug
102-P223 BRAK, Host: Rabbit, Species: Anti-Human, Synonyms: CXCL14; KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14 100 ug
chm-239 Recombinant Human BRAK (CXCL14), His Tag BRAK His 20
chm-001 Recombinant Human BRAK (CXCL14) BRAK 1mg
chm-001 Recombinant Human BRAK (CXCL14) BRAK 5
chm-239 Recombinant Human BRAK (CXCL14), His Tag BRAK His 5
chm-001 Recombinant Human BRAK (CXCL14) BRAK 20
chm-239 Recombinant Human BRAK (CXCL14), His Tag BRAK His 1mg
orb80651 Human BRAK protein CXCL14 Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10.66 kDa. The Human BRAK conta 5
103-M357 CXCL14 Anti-Mouse Host: Rat Cxcl14; KS1; Kec; BMAC; BRAK; NJAC; MIP-2g; Scyb14; AI414372; bolekine; MIP2gamma; 1110031L23Rik; 1200006I23Rik 100
103-M357 CXCL14, Host: Rat, Species: Anti-Mouse, Synonyms: Cxcl14; KS1; Kec; BMAC; BRAK; NJAC; MIP-2g; Scyb14; AI414372; bolekine; MIP2gamma; 1110031L23Rik 100 ug
28-583 HSF1 mediates the stress induced expression of heat shock proteins. 0.05 mg
28-584 HSF1 mediates the stress induced expression of heat shock proteins. 0.1 mg
DL-BRAK-Hu Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur