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Pubmed ID :20679243
Publication Date : //

Interaction of JMJD6 with single-stranded RNA.


JMJD6 is a Jumonji C domain-containing hydroxylase. JMJD6 binds alpha-ketoglutarate and iron and has been characterized as either a histone arginine demethylase or U2AF65 lysyl hydroxylase. Here, we describe the structures of JMJD6 with and without alpha-ketoglutarate, which revealed a novel substrate binding groove and two positively charged surfaces. The structures also contain a stack of aromatic residues located near the active center. The side chain of one residue within this stack assumed different conformations in the two structures. Interestingly, JMJD6 bound efficiently to single-stranded RNA, but not to single-stranded DNA, double-stranded RNA, or double-stranded DNA. These structural features and truncation analysis of JMJD6 suggest that JMJD6 may bind and modify single-stand RNA rather than the previously reported peptide substrates.

Authors : Hong Xia , Zang Jianye , White Janice , Wang Chao , Pan Cheol-Ho , Zhao Rui , Murphy Robert C , Dai Shaodong , Henson Peter , Kappler John W , Hagman James , Zhang Gongyi ,

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